Bir olgu nedeniyle varicella zoster ensefaliti ve tüberküloz menenjit birlikteliği

Yıl 2021, , 149 - 152, 21.12.2021

Salih Cesur , Fatoş Ersoy , Merve Sarı , Cigdem Ataman Hatipoglu , Esra Kaya Kılıç , Sami Kınıklı

https://doi.org/10.47582/jompac.971107

Öz

Bu yazıda literatürde nadiren bildirilen bir durum olan varicella zoster ensefaliti ile tüberküloz menenjiti birlikteliği olan 58 yaşında erkek hasta sunuldu. Orbitofrontal bölgede zona tanısıyla valasiklovir tedavisi alırken hastada varicella zoster virüse bağlı olarak ensefalit kliniği gelişti. Tedavi sonrası ateşinin düşmemesi üzerine yapılan incelemelerde beyin omurilik sıvısında polimeraz zincir reaksiyonu testinde Mycobacterium tuberculosis kompleks’in pozitif saptandı. Hastaya tüberküloz menenjit tanısı konuldu. Tedavi sonrasında hastanın ateşi ve klinik yakınmaları tamamen düzeldi.

Anahtar Kelimeler

Varicella zoster ensefaliti, tüberküloz menenjit, koinfeksiyon

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Coexistence of varicella zoster encephalitis and tuberculous meningitis due to a case

Öz

In this article, a 58-year-old male patient with coexistence of varicella zoster encephalitis and tuberculous meningitis, a condition rarely reported in the literature, is presented. While receiving valacyclovir treatment with the diagnosis of shingles in the orbitofrontal region, the patient developed encephalitis clinic due to varicella zoster virus. In the examinations made after the fever did not decrease after the treatment, the polymerase chain reaction test in the cerebrospinal fluid was positive for Mycobacterium tuberculosis complex. The patient was diagnosed with tuberculous meningitis. After the treatment, the patient’s fever and clinical complaints completely resolved.

Anahtar Kelimeler

Varicella zoster encephalitis, tuberculous meningitis, coinfection

Proje Numarası

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Kaynakça

• Whitley RJ. Chickenpox and herpes zoster (varicella zoster virus) In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Churchill Livingstone, 2015: 1731-7.
• Büyükdemirci A, Yüksekkaya E, Cesur S, Kılıç EK, Hatipoğlu ÇA, Kınıklı S. Herpes zoster ophthalmicus sonrasında gelişen ensefalit olgusu. Klimik Derg 2018; 31: 157-60.
• Peter G E Kennedy, Anne A Gershon. Clinical features of Varicella-Zoster virus infection. Viruses 2018; 10: 609.
• Garg RK. Tuberculous meningitis. Acta Neurol Scand 2010; 122: 75-90.
• Donovan J, Thwaites GE, Huynha J. Tuberculous meningitis: where to from here? Curr Opin Infect Dis 2020; 33: 259–66.
• Stahl JP. Update on HSV and VZV infections of the brain. Rev Neurol (Paris) 2019; 175: 442-4.
• Boucher A, Herrmann JL, Morand P, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect 2017; 47: 221-35.
• Dittrich T, Marsch S, Egli A, et al. Predictors of infectious meningitis or encephalitis: the yield of cerebrospinal fluid in a cross-sectional study. BMC Infect Dis 2020; 20: 304.
• Kaewpoowat Q, Salazar L, Aguilera E, Wootton SH, Hasbun R. Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes. Infection 2016; 44: 337-45.
• Aibar-Arregui MA, de Escalante-Yangüela B, Tejero-Juste C, Martín-Fortea MP. Mixed meningoencephalitis caused by Mycobacterium tuberculosis and varicella zoster virüs. Rev Neurol 2009; 48: 91-3.