A case of acute hepatitis associated with COVID-19 in a geriatric patient

Yıl 2021, Cilt: 2 Sayı: 3, 102 - 104, 08.09.2021

Kenan Çadırcı , Muharrem Bayrak

https://doi.org/10.47582/jompac.886900

Cited By: 1

Öz

Coronavirus 2019 disease (COVID-19) is a deadly disease that causes 44 million positive cases and over 1 million deaths worldwide. COVID-19 is a disease in which respiratory tract infectious diseases such as fever, shortness of breath, and cough are observed more frequently. It has been observed to cause liver damage in literature studies in addition to respiratory symptoms. Our case is a 77-year-old male having no systemic disease except hypertension. Fever of 38.2°C for four days, pulse 84/min, respiratory rate 18/min, blood pressure 136/82 mmHg, and oxygen saturation on room air was measured 92% by pulse oximetry. The patient who had aspartate aminotransferase (AST) 753 IU/L and alanine aminotransferase (ALT) 683 U/L in the tests in the emergency room was admitted to the infectious diseases service because of acute liver damage and the positive result of the COVID-19 PCR-RT test performed in the emergency department. The diagnosis of acute hepatitis associated with COVID-19 was made in our case, after excluding other causes of elevated liver enzymes. We aimed to contribute to the literature by presenting our case.

Anahtar Kelimeler

Coronavirus(COVID-19), acute hepatitis, infection

Geriatrik hastada COVID-19 ilişkili akut hepatit olgusu

Öz

Koronavirüs 2019 hastalığı (COVID-19) dünya genelinde 44 milyon pozitif vaka ve 1 milyonun üzerine ölüme sebep olan ölümcül bir hastalıktır. COVID-19 ateş, nefes darlığı ve öksürük gibi solunum yolu enfeksiyon hastalıkları bulgularının daha sık izlendiği bir hastalıktır. Solunumsal semptomlarının yanında literatür çalışmalarında karaciğer hasarına yol açtığı görülmüştür. Vakamız 77 yaşında erkek, hipertansiyon haricinde herhangi bir sistemik hastalığı yoktu. Dört gündür başlayan 38,2°C ateş, nabız 84/dk, solunum sayısı 18/dk, tansiyon 136/82 mmHg, oda havasında oksigen saturasyonu pulse oksimetri ile ölçümü %92’idi. Acil servisteki tetkiklerinde aspartat aminotransferaz (AST) 753 IU/L ve alanin aminotransferaz (ALT) 683 U/l olan hastanın akut karaciğer hasarı olması, acil serviste yapılan COVID-19 PCR-RT testinde pozitif olması nedeniyle enfeksiyon hastalıkları servisine yatırıldı. Vakamızda karaciğer enzim yüksekliği yapan diğer nedenler dışlandıktan sonra COVID-19 ilişkili akut hepatit olgusu tanısı konuldu. Olgumuzu literatüre sunarak katkı sağlamayı amaçladık.

Anahtar Kelimeler

Koranavirüs(COVİD- 19), akut hepatit, enfeksiyon

Kaynakça

• Johns Hopkins coronavirus resource center retrieved from https://coronavirus.jhu.edu/data/mortality at 08.02 pm. 28.10.2020.
• Téllez L, Martín Mateos RM. COVID-19 and liver disease: An update. Actualización en COVID-19 y enfermedad hepática. Gastroenterol Hepatol 2020; 43: 472-80.
• Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506.
• Xu L, Liu J, Lu M, Yang D, Zheng X. Liver injury during highly pathogenic human coronavirus infections. Liver Int 2020; 40: 998-1004.
• Bourgonje AR, Abdulle AE, Timens W, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol 2020; 251: 228-48.
• Feng G, Zheng KI, Yan QQ, et al. COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. J Clin Transl Hepatol 2020; 8: 18-24.
• Boregowda U, Aloysius MM, Perisetti A, Gajendran M, Bansal P, Goyal H. serum activity of liver enzymes is associated with higher mortality in COVID-19: a systematic review and meta-analysis. Front Med (Lausanne) 2020; 7: 431.
• Tian S, Xiong Y, Liu H, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol 2020; 33: 1007-14.
• Chau TN, Lee KC, Yao H, et al. SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology 2004; 39: 302-10.
• Alsaad KO, Hajeer AH, Al Balwi M, et al. Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection - clinicopathological and ultrastructural study. Histopathology 2018; 72: 516-24.
• Wander P, Epstein M, Bernstein D. COVID-19 presenting as acute hepatitis. Am J Gastroenterol 2020; 115: 941-2.
• Lagana SM, De Michele S, Lee MJ, et al. COVID-19 associated hepatitis complicating recent living donor liver transplantation. Arch Pathol Lab Med 2020; 10.5858/arpa.2020-0186-SA.