This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-(thiazol-4-yl)-3,7-dihydro-1H-purine-2,6-dione (5) exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 μM, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anti-cancer activity, which could be further investigated to enhance its biological potential.
Xanthine Heterocyclic compounds Antiproliferative activity Anti-cancer MTT
Birincil Dil | İngilizce |
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Konular | Organik Kimyasal Sentez, Biyolojik Olarak Aktif Moleküller |
Bölüm | ARAŞTIRMA MAKALELERİ |
Yazarlar | |
Yayımlanma Tarihi | 15 Mayıs 2024 |
Gönderilme Tarihi | 9 Ağustos 2023 |
Kabul Tarihi | 20 Kasım 2023 |
Yayımlandığı Sayı | Yıl 2024 |