Nanocarriers for Controlled Drug Delivery A convergence of Polymer and Nanochemistry

Abstract

Regarding improving the quality of health care strategies and other fields based on nanoscale technology, nanotechnology has been recognized as the most prevalent and commercially invented technology. In the near future, the pharmaceutical and biotechnology industries are likely to undergo significant changes due to the widespread adoption of nanoscale technology in drug delivery systems, that uses the polymeric nanoparticles that Polymeric nanoparticles have been extensively studied as particulate carriers in the pharmaceutical and medical fields, because they show promise as drug delivery systems as a result of their controlled- and sustained-release properties, subcellular size, and biocompatibility with tissue and cells. Several methods used for preparation of polymeric nanoparticles and after preparation of them they are most important particles that used in encapsulation of drugs such as PLGA, PLA, chitosan are used as encapsulation of anticancer drugs and antihormonal and antimalarial drugs and increase their release rates and also, they are used in field of dentistry and oral systems that are used in some diseases that cause infections, the use of polymeric nanoparticles with antibacterial drugs lead to decrease the infections . To achieve efficient drug delivery, it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signaling involved in pathobiology of the disease under consideration.

Keywords

• Nanochemistry,
• Polymeric nanoparticles,
• Drug delivery system

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