Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin

Şeyda Karaman Ersoy; Merve Akyüz; Kevser Sözgen Başkan

doi:10.18596/jotcsa.1608405

Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin

Abstract

Quercetin (QUE) is the most active compound in the flavone family, commonly found in the leaves, fruits, and flowers of many plants. The separation of QUE from various plant matrices has been a key research area due to its antioxidant, anti-inflammatory, antiviral, and antitumor properties. In this study, the conditions for synthesizing MMIPs and their use in QUE recovery were examined. Iron (II) chloride tetrahydrate (FeCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used to prepare magnetic nanoparticles, and Fe3O4 was synthesized. Tetraethyl orthosilicate (TEOS) was used to coat the resulting Fe3O4 surface with silica. [3-(methacryloxy)propyl] trimethoxysilane (γ-MPS) was used to functionalize the surface of the formed Fe3O4@TEOS structure. The synthesis was carried out using QUE as the template molecule; tetrahydrofuran (THF), ethanol (EtOH), and a solvent mixture of acetone and acetonitrile (ACN) (3:1, v/v) served as porogen solvents; acrylamide (AM), methacrylic acid (MAA), and 4-vinylpyridine (4-VP) were used as functional monomers; ethylene glycol dimethacrylate (EDMA) served as the cross-linker, and 2,2’-azobisisobutyronitrile (AIBN) was used as the initiator at different molar ratios (T:M:CrL, 1:4:20, 1:8:20, and 1:8:40). The recognition and selectivity properties of these polymers were evaluated based on absorbance values at 370 nm obtained through equilibrium assays, which used QUE solutions prepared in THF, ACN, and 50% (v/v) EtOH solvent mixtures at different ratios. It was established that the magnetic imprinted polymer prepared with a 50% (v/v) EtOH solvent mixture and molar ratios of 1:8:40 (QUE:4-VP:EDMA) exhibited the highest adsorption capacity and imprinting factor. Using the prepared QUE-MMIP, QUE was recovered with 33% efficiency from red onion peel extract.

Keywords

References

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Details

Primary Language

English

Subjects

Separation Science, Analytical Chemistry (Other)

Journal Section

Research Article

Authors

Şeyda Karaman Ersoy ^*
0000-0001-6131-348X
Türkiye

Merve Akyüz
0009-0004-2807-0243
Türkiye

Kevser Sözgen Başkan
0000-0002-3486-0231
Türkiye

Publication Date

September 14, 2025

Submission Date

January 2, 2025

Acceptance Date

June 10, 2025

Published in Issue

Year 2025 Volume: 12 Number: 3

DOI

https://doi.org/10.18596/jotcsa.1608405

IZ

https://izlik.org/JA93FG59JU

Cite

RIS / Bibtex

APA

Karaman Ersoy, Ş., Akyüz, M., & Sözgen Başkan, K. (2025). Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin. Journal of the Turkish Chemical Society Section A: Chemistry, 12(3), 155-168. https://doi.org/10.18596/jotcsa.1608405

AMA

1.Karaman Ersoy Ş, Akyüz M, Sözgen Başkan K. Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin. JOTCSA. 2025;12(3):155-168. doi:10.18596/jotcsa.1608405

Chicago

Karaman Ersoy, Şeyda, Merve Akyüz, and Kevser Sözgen Başkan. 2025. “Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin”. Journal of the Turkish Chemical Society Section A: Chemistry 12 (3): 155-68. https://doi.org/10.18596/jotcsa.1608405.

EndNote

Karaman Ersoy Ş, Akyüz M, Sözgen Başkan K (September 1, 2025) Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin. Journal of the Turkish Chemical Society Section A: Chemistry 12 3 155–168.

IEEE

[1]Ş. Karaman Ersoy, M. Akyüz, and K. Sözgen Başkan, “Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin”, JOTCSA, vol. 12, no. 3, pp. 155–168, Sept. 2025, doi: 10.18596/jotcsa.1608405.

ISNAD

Karaman Ersoy, Şeyda - Akyüz, Merve - Sözgen Başkan, Kevser. “Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin”. Journal of the Turkish Chemical Society Section A: Chemistry 12/3 (September 1, 2025): 155-168. https://doi.org/10.18596/jotcsa.1608405.

JAMA

1.Karaman Ersoy Ş, Akyüz M, Sözgen Başkan K. Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin. JOTCSA. 2025;12:155–168.

MLA

Karaman Ersoy, Şeyda, et al. “Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 12, no. 3, Sept. 2025, pp. 155-68, doi:10.18596/jotcsa.1608405.

Vancouver

1.Şeyda Karaman Ersoy, Merve Akyüz, Kevser Sözgen Başkan. Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin. JOTCSA. 2025 Sep. 1;12(3):155-68. doi:10.18596/jotcsa.1608405