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BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL
Abstract
Voltage-gated calcium channels are the primary mediators of depolarization-induced calcium entry into neurons [1]. While calcium channels are of critical importance to brain function, their inappropriate expression or dysfunction gives rise to a variety of neurological disorders, including, pain, epilepsy, migraine, and ataxia.
Molecular dynamics methods are the only physically valid methods for studying the structure function relations in ion channels. Applications of these methods to sodium and calcium channels are presented, which illustrate the multi-ion nature of the permeation mechanism in selective biological channels (as shown in Figure 1).
In this study, we present binding energies of single and multi-ion Na+ to the Ca++ channels.
Furthermore we interpret binding energies for constructing structure-function relationship of this channel.
Molecular dynamics methods are the only physically valid methods for studying the structure function relations in ion channels. Applications of these methods to sodium and calcium channels are presented, which illustrate the multi-ion nature of the permeation mechanism in selective biological channels (as shown in Figure 1).
In this study, we present binding energies of single and multi-ion Na+ to the Ca++ channels.
Furthermore we interpret binding energies for constructing structure-function relationship of this channel.
Keywords
References
- Tang, L., Gamal El-Din, T.M., Payandeh, J., Martinez, G.Q., Heard, T.M., Scheuer, T., Zheng, N., Catterall, W.A., Nature,505, 56-62, (2011).
Details
Primary Language
English
Subjects
-
Journal Section
-
Publication Date
January 30, 2015
Submission Date
January 22, 2015
Acceptance Date
-
Published in Issue
Year 2015 Volume: 2 Number: 2
APA
Baştuğ, T., Çavuş, M., & Kuyucak, S. (2015). BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL. Journal of the Turkish Chemical Society Section A: Chemistry, 2(2), 2-4. https://doi.org/10.18596/jotcsa.11320
AMA
1.Baştuğ T, Çavuş M, Kuyucak S. BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL. JOTCSA. 2015;2(2):2-4. doi:10.18596/jotcsa.11320
Chicago
Baştuğ, Turgut, Murat Çavuş, and Serdar Kuyucak. 2015. “BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL”. Journal of the Turkish Chemical Society Section A: Chemistry 2 (2): 2-4. https://doi.org/10.18596/jotcsa.11320.
EndNote
Baştuğ T, Çavuş M, Kuyucak S (January 1, 2015) BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL. Journal of the Turkish Chemical Society Section A: Chemistry 2 2 2–4.
IEEE
[1]T. Baştuğ, M. Çavuş, and S. Kuyucak, “BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL”, JOTCSA, vol. 2, no. 2, pp. 2–4, Jan. 2015, doi: 10.18596/jotcsa.11320.
ISNAD
Baştuğ, Turgut - Çavuş, Murat - Kuyucak, Serdar. “BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL”. Journal of the Turkish Chemical Society Section A: Chemistry 2/2 (January 1, 2015): 2-4. https://doi.org/10.18596/jotcsa.11320.
JAMA
1.Baştuğ T, Çavuş M, Kuyucak S. BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL. JOTCSA. 2015;2:2–4.
MLA
Baştuğ, Turgut, et al. “BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2, no. 2, Jan. 2015, pp. 2-4, doi:10.18596/jotcsa.11320.
Vancouver
1.Turgut Baştuğ, Murat Çavuş, Serdar Kuyucak. BINDING MECHANISM OF CALCIUM AND SODIUM ION OF CavAb CHANNEL. JOTCSA. 2015 Jan. 1;2(2):2-4. doi:10.18596/jotcsa.11320
