Synthesis of substituted quinolinone ketones derived with some five, six and seven-membered heterocycles

Year 2016, Volume: 3 Issue: 1, 27 - 45, 11.01.2016

Magdi Ahmed Hany Hassanin , Mohamed Abass , Shimaa Badran

Abstract

Abstract: The synthesis of a series of new quinolinyl ketones substituted with some five, six and seven-membered diaza-heterocycles is described. Efficient base or acid-catalyzed nucleophilic heterocyclization of 6-ethyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxaldehyde with a variety of nitrogen and/or carbon 1,2-, 1,3-, and 1,4-binucleophiles afforded the target ketones in good yields. The structure of all new products was established on basis of their spectral and analytical data.

Keywords

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