In this work, 15 different coumarin hydrazides were successfully synthesized
and screened for their antioxidant and antilipase activities. To do this,
firstly, salicylaldehyde derivatives and 2,2-dimethyl-1,3-dioxane-4,6-dione
(Meldrum's Acid) were reacted in ethanol in the presence of catalytic amount of pyridine to obtain
coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds
were treated with benzotriazole in dichloromethane by using thionyl chloride to
synthesized benzotriazole derivatives (2a-e).
Then, compounds 2a-e were reacted
with three commercial hydrazides (nicotinic hydrazide, benzhydrazide and
phenylacetichydrazide) in ethanol by using microwave irradiation and
conventional heating procedures to obtain final products (3-5a-e). Finally, these compounds were tested for their anti-oxidant
and anti-pancreatic lipase activities. The structure of newly synthesized
compounds was identified by 1H NMR, 13C NMR and elemental
analysis data.
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 1 Ocak 2018 |
Gönderilme Tarihi | 6 Şubat 2018 |
Kabul Tarihi | 16 Mart 2018 |
Yayımlandığı Sayı | Yıl 2018 |