Determination of Antimicrobial and Biological Activities of Salvia sclarea L. (Lamiaceae) Extracts

Abstract

In the present study, Salvia sclarea L. was collected during to flowering stage in 2016, Sarıcakaya (Eskişehir/Turkey) and dried medicinal plant materials were macerated with 70% MeOH. The antimicrobial activity of Salvia sclarea extracts was determined with minimum inhibitory concentration (MIC) assay against Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 29213 and Candida albicans ATCC 90028. The antibiofilm activity of Salvia sclarea extracts was determined against Staphylococcus aureus ATCC 29213 and Staphylococcus epidermidis ATCC 14990. And the preliminary cytotoxicity assessment of extracts was tested with Brine Shrimp Lethality Assay against model organism Artemia salina nauplii.  As a result, Salvia sclarea extract showed remarkably antibacterial activity while it showed no effect on Candida albicans ATCC 90028. Moreover, antibiofilm activity could not be determined. The lethality effect also could not be determined due to high dose concentrations.

Keywords

• Salvia,antimicrobial,antibiofilm,cytotoxicity

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