2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery

Abstract

Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO₂) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO₂ structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m²/g 2-chloro-benzoythiourea modified MCM-4, respectively. The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.

Keywords

• Drug delivery system(DDS),mesoporous MCM-41

References

1. 1. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem.Mater. 2001; 13(2):308-11.
2. 2. Wang, S. Ordered mesoporous materials for drug delivery. Micropor. Mesopor. Mat. 2009; 117(1-2): 1-9.
3. 3. Zeng W. Qian XF. Yin J. Zhu ZK. The drug delivery system of MCM-41 materials via co-condensation synthesis. Mater. Chem. Phys. 2006; 97(2-3): 437-41.
4. 4. Sousa A. Souza KC. Sousa EMB. Mesoporous silica/apatite nanocomposite: special synthesis route to control local drug delivery. Acta. Biomater. 2008; 4(3): 671-9.
5. 5. Qu F. Zhu G. Huang S. Li S. Sun J. Zhang D. Qiu S.Controlled release of Captopril by regulating the pore size and morphology of ordered mesoporous silica. Micropor. Mesopor. Mat. 2006; 92(1-3): 1-9.
6. 6. Mal NK. Fujiwara M. Tanaka Y. Taguchi T. Matsukata M. Photo-switched storage and release of guest molecules in the pore void of coumarin-modified MCM-41. Chem. Mater. 2003; 15(17): 3385-34.
7. 7. Aiello R. Cavallaro G. Giammona G. Pasqua L. Pierro P. Testa F. Mesoporous silicate as matrix for drug delivery systems of non-steroidal antinflammatory drugs. In Studies in Surface Science and Catalysis Elsevier. 2002; 142:1165-72.
8. 8. Cavallaro G. Pierro P. Palumbo FS. Testa F. Pasqua L. Aiello R. Drug delivery devices based on mesoporous silicate. Drug. Deliv. 2004; 11(1):41-6.

9. 9. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit 2007; 46(40):7548-58.
10. 10. Xu W. Xu Y. Wu D. Sun Y. Ibuprofen delivery systems based on monodispersed spherical MCM-41 materials. In Studies in Surface Science and Catalysis Elsevier. 2007; 170:861-5.
11. 11. Manzano M. Aina V. Arean CO. Balas F. Cauda V. Colilla M. Vallet-Regi M. Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chem. Eng. J. 2008; 137(1):30-7. 12. Carino IS. Pasqua L. Testa F. Aiello R. Puoci F. Iemma F. Picci N. Silica-based mesoporous materials as drug delivery system for methotrexate release. Drug. Deliv. 2007; 14(8):491-5.
12. 13. Nunes CD. Vaz PD. Fernandes AC. Ferreira P. Romao CC. Calhorda MJ. Loading and delivery of sertraline using inorganic micro and mesoporous materials. Eur. J. Pharm. Biopharm. 2007; 66(3):357-65.
13. 14. Vallet-Regi M. Ramila A. Del Real RP. Pérez-Pariente J. A new property of MCM-41: drug delivery system. Chem. Mater. 2001; 13(2):308-11.
14. 15. Popova M. Szegedi A. Mavrodinova V. Tušar NN. Mihály J. Klébert S. Yoncheva K. Preparation of resveratrol-loaded nanoporous silica materials with different structures. J. Solid State Chem. 2014; 219:37-42.
15. 16. Horcajada P. Ramila A. Perez-Pariente J. Vallet-Regı M. Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor. Mesopor. Mat. 2004; 68(1-3):105-9.
16. 17. Rámila A. Munoz B. Pérez-Pariente J. Vallet-Regí M. Mesoporous MCM-41 as drug host system. J. Sol-Gel Sci. Tech. 2003; 26(1-3):1199-202.
17. 18. Vallet‐Regí M. Balas F. Arcos D. Mesoporous materials for drug delivery. Angew. Chem.Int. Edit. 2007; 46(40):7548-58.
18. 19. Antochshuk V. Jaroniec M. Adsorption, thermogravimetric, and NMR studies of FSM-16 material functionalized with alkylmonochlorosilanes. J. Phys. Chem. B. 1999; 103(30):6252-61.
19. 20. Dash S. Murthy PN. Nath L. Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta. Pol. Pharm. 2010;67(3):217-23.