In this study, the synthesis of various geranyloxycoumarin derivatives from hydroxycoumarin was obtained in good yield under mild conditions using Cs2CO3. In the synthesis of geranyloxycoumarin derivatives, when 4-hydroxycoumarin reacts with geranyl bromide under mild conditions due to tautomeric keto-enol forms, 4-geranyoxycoumarin (3a), C-alkylated coumarin (3aa) and structure 3ab formed by hydrolysis and decarboxylation from 3aa were formed products. In addition, the alkylation reaction of 3-OH, 5-OH, 6-OH, 7-OH, and 8-OH coumarin except 4-OH group produced a high yield.
geranyloxycoumarin derivatives 4-hydroxycoumarin tautomeric keto-enol forms coumarin compounds geranyl bromide
Birincil Dil | İngilizce |
---|---|
Konular | Organik Kimya |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 28 Şubat 2022 |
Gönderilme Tarihi | 18 Eylül 2021 |
Kabul Tarihi | 23 Kasım 2021 |
Yayımlandığı Sayı | Yıl 2022 |