This study aims to offer a voltammetric method for determining the antipsychotic drug flupentixol from serum samples. According to pH and scan rate studies, the oxidation behavior of flupentixol at boron-doped diamond electrode was found as irreversible and diffusion-controlled. In order to determine flupentixol from bulk form and serum samples, differential pulse voltammetry was preferred as the working method because of the repeatability. Linear responses were obtained in the range of 6.0×10-7 – 8.0×10-6 M and 8.0×10-7 – 1.0×10-5 M for bulk form and serum samples in pH 2.0 Britton-Robinson buffer solution, with detection limit values of 1.09×10-7 M and 1.08×10-7 M, respectively. Required validation parameters were also studied and according to recovery from serum samples (99.91 %) and precision studies, it can be said that developed method was accurate and precise.
Flupentixol voltammetry boron-doped diamond electrode serum validation
Birincil Dil | İngilizce |
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Konular | Analitik Kimya |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 31 Ağustos 2022 |
Gönderilme Tarihi | 21 Eylül 2021 |
Kabul Tarihi | 15 Nisan 2022 |
Yayımlandığı Sayı | Yıl 2022 |