Boronic acid functionalized silica microparticles for isolation of flavonoids from Hypericum perforatum

Yıl 2018, Cilt: 5 Sayı: 1, 41 - 60, 01.09.2017

Onur Cetinkaya , Hüseyin Çiçek , Şeyda Kıvrak Gülsen Çayan

https://doi.org/10.18596/jotcsa.307440

Öz

We have selectively separated cis- and/or vicinal-diol-containing
flavonoids from Hypericum perfaratum (HP)
by adsorption/desorption using aminophenylboronic acid (APBA) functionalized
uniform (1.6 μm) silica microparticles (BASPs) synthesized via the Stöber method. Silica particles were alkylated by its
terminal –OH with 3-aminopropyl trimethoxysilane (APTS), glutaraldehyde (GA)
and APBA. The results from model adsorption studies indicated that these microparticles
selectively adsorbed quercetin and rutin but partially apigenin. The
antioxidant and antiradical activities of the desorption solution were slightly
higher than that of the post-adsorption solution. These results indicated that the
BASP selectively adsorbed the cis- and/or vicinal antioxidant and antiradical flavonoids.

Anahtar Kelimeler

Antioxidants, Boronic Acid, Free Radical Scavengers, Hypericum Perforatum, Microsphere

Kaynakça

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