Synthesis of Some New Benzimidazole Derivatives Containing Chlorine and Investigation of Their Antioxidant and Anti-urease Activities

Year 2018, Volume: 5 Issue: 2, 971 - 980, 01.01.2018

Nesrin Karaali

https://doi.org/10.18596/jotcsa.440202

Cited By: 7

Abstract

In this work, the synthesis of 2-substituted
benzimidazole compound containing chlorine
(1) was carried out and then
converted to the ester (2) and hydrazide (3) derivatives respectively. In the
next steps, the hydrazide compound (3)
was reacted with the appropriate reagents to give the thiadiazole (8-10) and triazole (11-13) derivatives. Synthesis of the
compound 4 was carried out as a
result of the interaction of the ester derivative compound (2) with morpholine. The structures of
all synthesized compounds were elucidated by FT-IR, ¹H NMR, ¹³C
NMR and elemental analysis spectroscopic methods. Also, the antioxidant and
urease enzyme inhibition properties of these compounds were also investigated.

Keywords

Benzimidazole, triazole, thiadiazole

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