The
nickel(II) complexes containing 3-methoxy-salicylaldehyde-N4-R thiosemicarbazones
(R:-H2,-propyl)with triphenylphosphine coligands have been
synthesized. The structure of Ni(II)-centered metal complex was approved by
elemental analysis and melting point. The solid-state structure of complex 2 bearing PPh3 as co-ligand was
clarified by single crystal X-ray crystallography, which revealed square planar
geometry around Ni(II) ion. Thiosemicarbazone
ligands are coordinated by ONS mode to nickel(II). The potential of these complexes to inhibit the DNase I enzyme, which
uses DNA as a substrate, was investigated in vitro. The results revealed that
the compounds inhibited the DNase enzyme in directly and/or indirectly (by
masking of DNA molecules) at ≥0.1 µg/ml concentrations in vitro.
Nickel(II) complexes thiosemicarbazones X-ray crystallography DNase I
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 1 Eylül 2018 |
Gönderilme Tarihi | 19 Ekim 2018 |
Kabul Tarihi | 25 Aralık 2018 |
Yayımlandığı Sayı | Yıl 2018 Cilt: 5 Sayı: 3 |