In this study, the electrochemical behaviors of cephalexin
and cefazoline on disposable pencil graphite electrode were investigated in phosphate
buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis
was performed in phosphate buffer at the optimum medium determined for each
sample. Validation parameters were studied to show the correctness,
sensitivity, and consistency of the method developed for the cephalosporins. It
was concluded that disposable pencil graphite electrode could be used
effectively in the determination of cephalosporins. The limits of detection (S/N=3)
were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline,
respectively. The analysis of these compounds in pharmaceutical formulations
and biological samples was carried out at defined optimum conditions. The
recovery values were around 100%.
electrochemical biosensors pencil graphite electrode voltammetric methods Beta-lactam antibiotics
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 15 Haziran 2019 |
Gönderilme Tarihi | 10 Ekim 2018 |
Kabul Tarihi | 7 Mayıs 2019 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 6 Sayı: 2 |