In this work, a series of histamine Schiff bases H(1-20) were synthesized by reacting
histamine and substituted aldehydes A(1-20).
The compounds were assayed for antioxidant properties by using different
bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation
radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal
chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase
(BChE) inhibition profiles were also assessed. In general, the synthesized
compounds showed weak antioxidant activity against all tested methods, but some
of the compounds showed great inhibition potency against AChE and BChE enzymes.
Specifically, compound H9 showed
effective inhibition potency against both enzymes with % inhibition of 97.03
and 93.64, respectively.
Birincil Dil | İngilizce |
---|---|
Konular | Biyokimya ve Hücre Biyolojisi (Diğer) |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 15 Haziran 2019 |
Gönderilme Tarihi | 2 Şubat 2019 |
Kabul Tarihi | 30 Mart 2019 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 6 Sayı: 2 |