The antimicrobial properties of silver compounds
and biological properties of benzimidazole derivatives have been well known for
many years. In the present study, in terms of their biological potential, six
novel silver(I)-N-alkylbenzimidazole derivatives were synthesized in order to
examine their carbonic anhydrase (CA) inhibitory properties. All complexes were
characterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic
methods and elemental analyses. The inhibitory properties of all complexes were
tested on the esterase activity of human CA I and II (hCA I and hCA II).
Acetazolamide was used as a standard. All complexes inhibited the hCA I and hCA
II activity in the range of 27.37-29.58 µM and 20.93-27.25 µM, respectively.
|Konular||Kimya, Ortak Disiplinler|
: 29 Mart 2019
|Vancouver||Karataş M , Ergün A . Synthesis, Characterization, and Carbonic Anhydrase Inhibitory Properties of Silver(I) Complexes of Benzimidazole Derivatives. Journal of the Turkish Chemical Society Section A: Chemistry. 2019; 253-260.|