Yıl 2019, Cilt 6 , Sayı 2, Sayfalar 253 - 260 2019-06-15

Synthesis, Characterization, and Carbonic Anhydrase Inhibitory Properties of Silver(I) Complexes of Benzimidazole Derivatives

Mert Ogun KARATAŞ [1] , Adem ERGÜN [2]


The antimicrobial properties of silver compounds and biological properties of benzimidazole derivatives have been well known for many years. In the present study, in terms of their biological potential, six novel silver(I)-N-alkylbenzimidazole derivatives were synthesized in order to examine their carbonic anhydrase (CA) inhibitory properties. All complexes were characterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic methods and elemental analyses. The inhibitory properties of all complexes were tested on the esterase activity of human CA I and II (hCA I and hCA II). Acetazolamide was used as a standard. All complexes inhibited the hCA I and hCA II activity in the range of 27.37-29.58 µM and 20.93-27.25 µM, respectively. 

Benzimidazole, silver, carbonic anhydrase, inhibition
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Birincil Dil en
Konular Kimya, Ortak Disiplinler
Bölüm Makaleler
Yazarlar

Orcid: 0000-0001-8500-2088
Yazar: Mert Ogun KARATAŞ (Sorumlu Yazar)
Kurum: İnönü Üniversitesi
Ülke: Turkey


Orcid: 0000-0003-4647-6058
Yazar: Adem ERGÜN (Sorumlu Yazar)
Kurum: Balıkesir Üniversitesi
Ülke: Turkey


Tarihler

Başvuru Tarihi : 29 Mart 2019
Kabul Tarihi : 21 Mayıs 2019
Yayımlanma Tarihi : 15 Haziran 2019

Vancouver Karataş M , Ergün A . Synthesis, Characterization, and Carbonic Anhydrase Inhibitory Properties of Silver(I) Complexes of Benzimidazole Derivatives. Journal of the Turkish Chemical Society Section A: Chemistry. 2019; 253-260.