Yıl 2019,
Cilt: 6 Sayı: 3, 429 - 432, 20.10.2019
Hülya Çelik Onar
Fatma Ceren Anlaş
Hasniye Yaşa
Fulya Üstün Alkan
Belma Hasdemir
Tülay Bakırel
Kaynakça
- 1. Venkatesh P. Synthesis, characterization and antimicrobial activity of various schiff bases complexes of Zn(II) and Cu(II) ions. Asian J Pharm. Hea. Sci. 2011; 1: 8-11.
- 2. Hussein MA, Omar RH, Farghaly HS. Design, synthesis, structure elucidation and biochemical evaluation of some schiff’s base derivatives bearing pyrazolo [3,4-D] pyrimidine-4-ones. Int. J. Acad Res. 2011; 3/2: 454-462.
- 3. Nair R, Shah A, Baluja S, Chanda S. Synthesis and antibacterial activity of some schiff base complexes. J. Serb. Chem. Soc. 2006; 71: 733-44.
- 4. Sathe BS, Jaychandran E, Jagtap VA, Sreenivasa GM. Synthesis characterization and anti-inflammatory evaluation of new fluorobenzothiazole schiff’s bases. Int. J. Pharm. Res. Dev. 2011; 3: 164-69.
- 5. Pandey A, Dewangan D, Verma S, Mishra A, Dubey RD. Synthesis of schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazole and its analgesic, antiinflammatory, antibacterial and antitubercular activity. Int. J. Chem. Tech. Res. 2011; 3: 178-84.
- 6. Fahmy HH, El-Eraky W, (2001) Synthesis and evaluation of analgesic and anti-inflammatory activities of O- substituted salicylamides. Arch. Pharm. Res. 24, 171-179.
- 7. Chinnasamy RP, Sundararagan R, Govindaraj S, (2010) Synthesis, characterization and analgesic activity of novel Schiff base isatin derivatives. J. Adv. Pharm. Technol. Res. 1, 342-347.
- 8. Ali MM, Jesmin M, Salam SMA, Khanam JA, Islam MF, Islam MN, (2009) Pesticidal activities of some schiff bases derived from benzoin, salicylaldehde, aminophenol and 2, 4- dinitrophenylhydrazine. J. Sci. Res. 1, 641-646.
- 9. Jesmin M, Ali MM, Islam MN, (2008) Pesticidal Activity of some Schiff Base Complexes Derived from some Divalent Metal Acetates, Glycine and Salicylaldehyde. J. Sci. Found. 6, 49-56.
- 10. Jon JK, Swieczkowski DM, Anthony JC, Truant JP, (1972) Fatty Acids and Derivatives as Antimicrobial Agents. Antimicrob. Agents Chemother. 2/1, 23-28.
- 11. Maag H, (1984) Fatty acid derivatives: Important surfactants for household, cosmetic and industrial purposes. J. Am. Oil Chem. Soc. 61, 259-267.
- 12. Pasha MA, Nanjundaswamy HM, (2004) Reductive fission of azoarenes to aminoarenes by aluminium/hydrazine hydrate. J. Chem. Res. 750-752.
- 13. Hartley D, Kidd H, (1987) The Agrochemicals Hand Book, 2nd ed.; Royal Society of Chemistry: Nottingham, p 215.
- 14. Maurer EW, Smith FD, (1980) Fatty acid amides and anilides, syntheses and antimicrobial properties. J. Am. Oil Chem. Soc. 57, 98-103.
- 15. Shaikh MMA, Azad MAK, Jesmin M, Ahsan S, Rahman MM, Kraham JA, Islam MN, Shahria SMS, (2012) In vivo anticancer activity of vanillin semicarbazone. Asian Pac. J. Trop. Biomed. 438-442.
- 16. Çelik H, Özeriş S, (1996) Synthesis of Even Numbered of (2-12) Monohydroxy Eicosanoic Acid Isomers. Chim. Acta Turc. 24, 23-27.
ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES
Yıl 2019,
Cilt: 6 Sayı: 3, 429 - 432, 20.10.2019
Hülya Çelik Onar
Fatma Ceren Anlaş
Hasniye Yaşa
Fulya Üstün Alkan
Belma Hasdemir
Tülay Bakırel
Öz
This study was undertaken to examine the possible
cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic
acids (3.125 – 100 µM)
on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50
concentrations were recorded at 1.952 µM and 54.00 µM, respectively.
Kaynakça
- 1. Venkatesh P. Synthesis, characterization and antimicrobial activity of various schiff bases complexes of Zn(II) and Cu(II) ions. Asian J Pharm. Hea. Sci. 2011; 1: 8-11.
- 2. Hussein MA, Omar RH, Farghaly HS. Design, synthesis, structure elucidation and biochemical evaluation of some schiff’s base derivatives bearing pyrazolo [3,4-D] pyrimidine-4-ones. Int. J. Acad Res. 2011; 3/2: 454-462.
- 3. Nair R, Shah A, Baluja S, Chanda S. Synthesis and antibacterial activity of some schiff base complexes. J. Serb. Chem. Soc. 2006; 71: 733-44.
- 4. Sathe BS, Jaychandran E, Jagtap VA, Sreenivasa GM. Synthesis characterization and anti-inflammatory evaluation of new fluorobenzothiazole schiff’s bases. Int. J. Pharm. Res. Dev. 2011; 3: 164-69.
- 5. Pandey A, Dewangan D, Verma S, Mishra A, Dubey RD. Synthesis of schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazole and its analgesic, antiinflammatory, antibacterial and antitubercular activity. Int. J. Chem. Tech. Res. 2011; 3: 178-84.
- 6. Fahmy HH, El-Eraky W, (2001) Synthesis and evaluation of analgesic and anti-inflammatory activities of O- substituted salicylamides. Arch. Pharm. Res. 24, 171-179.
- 7. Chinnasamy RP, Sundararagan R, Govindaraj S, (2010) Synthesis, characterization and analgesic activity of novel Schiff base isatin derivatives. J. Adv. Pharm. Technol. Res. 1, 342-347.
- 8. Ali MM, Jesmin M, Salam SMA, Khanam JA, Islam MF, Islam MN, (2009) Pesticidal activities of some schiff bases derived from benzoin, salicylaldehde, aminophenol and 2, 4- dinitrophenylhydrazine. J. Sci. Res. 1, 641-646.
- 9. Jesmin M, Ali MM, Islam MN, (2008) Pesticidal Activity of some Schiff Base Complexes Derived from some Divalent Metal Acetates, Glycine and Salicylaldehyde. J. Sci. Found. 6, 49-56.
- 10. Jon JK, Swieczkowski DM, Anthony JC, Truant JP, (1972) Fatty Acids and Derivatives as Antimicrobial Agents. Antimicrob. Agents Chemother. 2/1, 23-28.
- 11. Maag H, (1984) Fatty acid derivatives: Important surfactants for household, cosmetic and industrial purposes. J. Am. Oil Chem. Soc. 61, 259-267.
- 12. Pasha MA, Nanjundaswamy HM, (2004) Reductive fission of azoarenes to aminoarenes by aluminium/hydrazine hydrate. J. Chem. Res. 750-752.
- 13. Hartley D, Kidd H, (1987) The Agrochemicals Hand Book, 2nd ed.; Royal Society of Chemistry: Nottingham, p 215.
- 14. Maurer EW, Smith FD, (1980) Fatty acid amides and anilides, syntheses and antimicrobial properties. J. Am. Oil Chem. Soc. 57, 98-103.
- 15. Shaikh MMA, Azad MAK, Jesmin M, Ahsan S, Rahman MM, Kraham JA, Islam MN, Shahria SMS, (2012) In vivo anticancer activity of vanillin semicarbazone. Asian Pac. J. Trop. Biomed. 438-442.
- 16. Çelik H, Özeriş S, (1996) Synthesis of Even Numbered of (2-12) Monohydroxy Eicosanoic Acid Isomers. Chim. Acta Turc. 24, 23-27.