Yıl 2021, Cilt 8 , Sayı 1, Sayfalar 187 - 194 2021-02-28

Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma

Cem YAMALI [1] , Halise İnci GÜL [2]

In anticancer drug research, there is a need for the synthesis of compounds with selective cytotoxicity compared to the drugs in the market. The current study aimed to determine the cytotoxicities of the bis Mannich bases 1-9 towards human oral squamous cell carcinoma (OSCC). Mannich bases showed cytotoxicity in low micromolar in the range of 1.7-27 µM against OSCC cell lines. The compounds 5 with the highest potency selectivity expression (PSE) value (318.1) and 7 with the highest tumor selectivity (TS) values (TS1:11.2, TS2:15.8) showed promising selective cytotoxicity towards cancer cell lines. According to Western blot analysis, representative compound 7 induced the activation of caspase-3 in HSC-2 cells. These results may suggest that the apoptosis pathway may be one of the possible mechanisms of the actions and lead compound 7 can be subjected to further bioassays.
Mannich, anticancer, apoptosis
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Birincil Dil en
Konular Kimya, Ortak Disiplinler
Yayınlanma Tarihi Winter
Bölüm Makaleler

Orcid: 0000-0002-4833-7900
Yazar: Cem YAMALI (Sorumlu Yazar)
Ülke: Turkey

Orcid: 0000-0001-6164-9602
Yazar: Halise İnci GÜL
Ülke: Turkey

Destekleyen Kurum Research Foundation of Ataturk University
Proje Numarası 2015-322
Teşekkür The authors are thankful to Hiroshi Sakagami (Meikai University, Japan) and Noriyuki Okudaira (Meikai University, Japan) for biological studies.

Başvuru Tarihi : 27 Ekim 2020
Kabul Tarihi : 15 Aralık 2020
Yayımlanma Tarihi : 28 Şubat 2021

Vancouver Yamalı C , Gül H . Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma. Journal of the Turkish Chemical Society Section A: Chemistry. 2021; 8(1): 187-194.