Yıl 2021, Cilt 8 , Sayı 1, Sayfalar 239 - 248 2021-02-28

Monoamine Oxidase Inhibitory Effects of Medicinal Plants in Management of Alzheimer's Disease

Tuba EGE [1] , Hayriye ŞELİMEN [2]

Alzheimer's disease is the most common progressive neurodegenerative disorder that effects large population of society especially elderly people. Environmental and/or genetic factors contribute Alzheimer's disease to become a pivotal health problem but this relationship remains ambiguous. Globally growing prevalence of Alzheimer’s disease requires to understand cellular pathways that lead to Alzheimer’s disease and to develop new strategies for prevention and treatment. Elevated monoamine oxidase (MAO) enzymes activity with ages is associated with etiology of Alzheimer's disease. Inhibition of monoamine oxidase enzyme can protect from neuronal damage, thus it become one of the key pathway for management of Alzheimer’s disease. Using bioactive compounds from medicinal plants as potential monoamine oxidase inhibitors might be a better solution considering undesired side effects of synthetic drugs on human body. The purpose of this review is to implicate the importance of pharmacophore analysis which explains pharmacological properties of medicinal plants and interaction of bioactive compound from plants with MAO enzyme.
Monoamine oxidase, Alzheimer's disease, bioactive compounds
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Birincil Dil en
Konular Biyokimya ve Moleküler Biyoloji
Yayınlanma Tarihi Winter

Orcid: 0000-0003-1574-171X
Yazar: Tuba EGE (Sorumlu Yazar)
Ülke: Turkey

Orcid: 0000-0002-3533-3628
Yazar: Hayriye ŞELİMEN
Ülke: Turkey


Başvuru Tarihi : 10 Kasım 2020
Kabul Tarihi : 27 Aralık 2020
Yayımlanma Tarihi : 28 Şubat 2021

Vancouver Ege T , Şelimen H . Monoamine Oxidase Inhibitory Effects of Medicinal Plants in Management of Alzheimer's Disease. Journal of the Turkish Chemical Society Section A: Chemistry. 2021; 8(1): 239-248.