Yıl 2021, Cilt 8 , Sayı 1, Sayfalar 329 - 342 2021-02-28

Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species

Duygu TAŞKIN [1] , Talip ŞAHİN [2] , Mücahit ÖZDEMİR [3] , Bahattin YALCİN [4]

In this study, the anti-cholinesterase activities of different extracts of Achillea lycaonica, A. vermicularis and A. nobilis L. subsp. neilreichii (Kerner) Formanek species were examined and then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, and Pb) of the plants were analysed by ICP-MS. The pharmacokinetic properties of the phenolic compounds of these plants previously analyzed by us and the ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) profiles of the trace elements we identified in this study were estimated. According to the data obtained, it was determined that all three plants showed high acetyl-cholinesterase inhibition activity. The concentration of trace elements was lower than that declared by WHO, except for the A. lycaonica. It was determined that V, Cr, Fe, Co, and As metals in A. lycaonica exceeded the limit values determined by WHO. According to ADMET estimates, it is thought that the toxic values of all three plants are not high, and therefore the use of A. nobilis and A. vermicularis plants does not pose any health risk but A lycaonica should be used carefully due to the heavy metals.
Phenolic compounds, ADMET, ICP-MS, cholinesterase inhibitory
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Birincil Dil en
Konular Kimya, Analitik
Yayınlanma Tarihi Winter
Bölüm Makaleler

Orcid: 0000-0002-5279-0900
Yazar: Duygu TAŞKIN (Sorumlu Yazar)
Ülke: Turkey

Orcid: 0000-0002-1031-9715
Yazar: Talip ŞAHİN
Kurum: Marmara University
Ülke: Turkey

Orcid: 0000-0002-0840-4953
Yazar: Mücahit ÖZDEMİR
Kurum: Marmara University
Ülke: Turkey

Orcid: 0000-0003-4448-1101
Yazar: Bahattin YALCİN
Kurum: Marmara University
Ülke: Turkey

Teşekkür Thanks to Dr. Ismail Senkardes, Dr.Ahmet Dogan, and Dr. Turan Arabaci, who identified the plants.

Başvuru Tarihi : 29 Aralık 2020
Kabul Tarihi : 17 Ocak 2021
Yayımlanma Tarihi : 28 Şubat 2021

Vancouver Taşkın D , Şahin T , Özdemir M , Yalcin B . Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species. Journal of the Turkish Chemical Society Section A: Chemistry. 2021; 8(1): 329-342.