Synthesis of Geranyloxycoumarin Derivatives under Mild Conditions Using Cs2CO3

Yıl 2022, Cilt: 9 Sayı: 1, 57 - 66, 28.02.2022

Sumi Hwang Eonjoo Roh

https://doi.org/10.18596/jotcsa.996363

Öz

In this study, the synthesis of various geranyloxycoumarin derivatives from hydroxycoumarin was obtained in good yield under mild conditions using Cs2CO3. In the synthesis of geranyloxycoumarin derivatives, when 4-hydroxycoumarin reacts with geranyl bromide under mild conditions due to tautomeric keto-enol forms, 4-geranyoxycoumarin (3a), C-alkylated coumarin (3aa) and structure 3ab formed by hydrolysis and decarboxylation from 3aa were formed products. In addition, the alkylation reaction of 3-OH, 5-OH, 6-OH, 7-OH, and 8-OH coumarin except 4-OH group produced a high yield.

Anahtar Kelimeler

geranyloxycoumarin derivatives, 4-hydroxycoumarin, tautomeric keto-enol forms, coumarin compounds, geranyl bromide

Kaynakça

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