Design, Synthesis and Structural Characterization of Novel Thioanthraquinone Analogues from 1,5-Dichloroanthraquinone

Year 2023, Volume: 10 Issue: 3, 671 - 676, 30.08.2023

Funda Özkök

https://doi.org/10.18596/jotcsa.1240673

Cited By: 2

Abstract

Anthraquinone and its derivatives are considered intermediate agents with superior properties due to their activities in chemical and biological reaction. A new, economical, practical and one-step synthesis method was developed by our research team for the synthesis of amino and thioanthraquinones in previous studies (1). With this synthesis method, thioanthraquinone analogs 2(a-d) were obtained from 1,5-Dichloroanthraquinone (1) and bioactive thiols. The synthesized organic molecules were purified by column chromatography and their structures were identified with spectroscopic methods. Fluorescence analyzes of synthesized thioanthraquinone analogues were performed. It was determined that all thioanthraquinone analogues synthesized and characterized in the study showed fluorescence activity. These new analogues with fluorescence are expected to find application in drug delivery systems and sensor studies.

Keywords

Anthraquinone, Thiol, Organic Synthesis, Florescence, Spectroscopic Analysis

Thanks

I am grateful to Istanbul University-Cerrahpaşa Chemistry Department, Eskişehir Osmangazi University Central Research Laboratory Application and Research Center (ARUM) and Kastamonu University Central Research Laboratory Application and Research Center for laboratory and analysis.

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