General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC)

Tuna Demirci

doi:10.58692/jotcsb.1731818

General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC)

Abstract

1,4-Dihydropyridine (DHP) derivatives are an important class of organic compounds known for their broad biological and pharmacological activities, particularly as calcium channel blockers, which make them valuable in medicinal chemistry. Given their significance, developing efficient and sustainable synthetic methods for these derivatives is crucial. In this study, we present a green, one-pot Hantzsch synthesis of 1,4-dihydropyridines using a Scrap Automobile Catalyst (SAC) as a sustainable and reusable heterogeneous catalyst. The multicomponent reaction was carried out under mild conditions using ammonium acetate in ethanol (EtOH) with various aldehydes and 1,3-diketones. The results demonstrate that the SAC-catalysed reaction proceeds efficiently, with electron-withdrawing substituents accelerating the reaction, achieving completion in just 1.5–2 hours. In contrast, reactions involving benzaldehyde required longer reaction times (up to 4 hours) but still afforded a high yield of 88%. This approach not only offers a rapid, high-yielding, and environmentally benign synthetic route but also provides an innovative solution for the valorisation of difficult-to-recycle automotive waste, aligning with the principles of green chemistry. The SAC catalyst proved to be reusable, further enhancing the sustainability of the process. This study highlights the potential of waste-derived catalysts in organic synthesis, offering a cost-effective and eco-friendly alternative to conventional method.

Keywords

Project Number

Düzce University Scientific Research Projects (No. 2020.01.01.1101) in this study.

Ethical Statement

The author declares that they have no conflicts of interest.

Thanks

I would like to acknowledge the financial support of Düzce University Scientific Research Projects (No. 2020.01.01.1101) in this study.

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Details

Primary Language

English

Subjects

Chemical Reaction

Journal Section

Research Article

Authors

Tuna Demirci ^*
0000-0001-8933-4944
Türkiye

Publication Date

September 15, 2025

Submission Date

July 1, 2025

Acceptance Date

August 1, 2025

Published in Issue

Year 2025 Volume: 8 Number: 2

DOI

https://doi.org/10.58692/jotcsb.1731818

IZ

https://izlik.org/JA33GD88HB

Cite

RIS / Bibtex

APA

Demirci, T. (2025). General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC). Journal of the Turkish Chemical Society Section B: Chemical Engineering, 8(2), 223-236. https://doi.org/10.58692/jotcsb.1731818

AMA

1.Demirci T. General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC). JOTCSB. 2025;8(2):223-236. doi:10.58692/jotcsb.1731818

Chicago

Demirci, Tuna. 2025. “General Synthesis Method of Hantzsch Dihydropyridine Using Scrap Automobile Catalyst (SAC)”. Journal of the Turkish Chemical Society Section B: Chemical Engineering 8 (2): 223-36. https://doi.org/10.58692/jotcsb.1731818.

EndNote

Demirci T (September 1, 2025) General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC). Journal of the Turkish Chemical Society Section B: Chemical Engineering 8 2 223–236.

IEEE

[1]T. Demirci, “General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC)”, JOTCSB, vol. 8, no. 2, pp. 223–236, Sept. 2025, doi: 10.58692/jotcsb.1731818.

ISNAD

Demirci, Tuna. “General Synthesis Method of Hantzsch Dihydropyridine Using Scrap Automobile Catalyst (SAC)”. Journal of the Turkish Chemical Society Section B: Chemical Engineering 8/2 (September 1, 2025): 223-236. https://doi.org/10.58692/jotcsb.1731818.

JAMA

1.Demirci T. General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC). JOTCSB. 2025;8:223–236.

MLA

Demirci, Tuna. “General Synthesis Method of Hantzsch Dihydropyridine Using Scrap Automobile Catalyst (SAC)”. Journal of the Turkish Chemical Society Section B: Chemical Engineering, vol. 8, no. 2, Sept. 2025, pp. 223-36, doi:10.58692/jotcsb.1731818.

Vancouver

1.Tuna Demirci. General Synthesis Method of Hantzsch dihydropyridine Using Scrap Automobile Catalyst (SAC). JOTCSB. 2025 Sep. 1;8(2):223-36. doi:10.58692/jotcsb.1731818