Yıl 2020, Cilt 1 , Sayı 1, Sayfalar 1 - 6 2020-04-01

Corneal and conjunctival infections are common ocular diseases; however, sometimes lead to blindness when neglected. Despite most of the ocular drug delivery systems are in eye drop form, they suffer from poor retention on the ocular surface and low ocular bioavailability leading to unsatisfactory results even with repeated treatment. Therefore, there is a need for more effective drug delivery systems for the ocular application. The present study was carried out to demonstrate that ocular inserts effectively delivers a significant concentration of drug with topical administration for the treatment of fungal infections with the help of extended residence time on the ocular surface. Chitosan-based inserts were prepared by the freeze-drying method. The prepared inserts were evaluated for various parameters. Layered structures were revealed with scanning electron microscopy analyses. Thermal and structural behaviors were analyzed by differential scanning calorimetry and Fourier-transform infrared spectroscopy with nuclear magnetic resonance analyses, respectively. Drug contents were evaluated by a validated HPLC method. In vitro release studies were also performed in simulated tear fluid at 34±1°C for 48 hours. Analyses results revealed that chitosan-based ocular inserts were suitable systems for posaconazole delivery for the treatment of severe ocular fungal infections.
Chitosan, In-Vitro Release, Ocular Bioavailability, Ocular Inserts, Posaconazole
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Birincil Dil en
Konular Eczacılık, Farmakoloji ve Eczacılık
Yayınlanma Tarihi 2020 Vol 1(1)
Bölüm Research Articles
Yazarlar

Orcid: 0000-0000-0000-0000
Yazar: Kadir AYKAÇ
Kurum: ECZACILIK FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-7979-0089
Yazar: Evrim YENİLMEZ
Kurum: ANADOLU UNIVERSITY FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0000-0000-0000
Yazar: Müzeyyen DEMİREL
Kurum: ANADOLU UNIVERSITY FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0003-2104-2069
Yazar: Ebru BAŞARAN (Sorumlu Yazar)
Kurum: Anadolu University, Faculty of Pharmacy
Ülke: Turkey


Destekleyen Kurum Anadolu University Scientific Research Project Foundation
Proje Numarası BAP No:1901S006
Teşekkür The study was financed by Anadolu University Scientific Research Project Foundation (BAP No:1901S006). Authors would like to thank to BIBAM management for SEM, and DOPNA-LAB for FT-IR and 1H-NMR analyses.
Tarihler

Başvuru Tarihi : 6 Mart 2020
Kabul Tarihi : 14 Mayıs 2020
Yayımlanma Tarihi : 1 Nisan 2020

Bibtex @araştırma makalesi { jpharmtech700080, journal = {Journal of Pharmaceutical Technology}, issn = {}, eissn = {2717-7904}, address = {Anadolu Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Abd Tepebaşı Eskişehir}, publisher = {Mustafa Sinan KAYNAK}, year = {2020}, volume = {1}, pages = {1 - 6}, doi = {10.37662/jpt.2020.0}, title = {Posaconazole loaded ocular inserts for antifungal activity}, key = {cite}, author = {Aykaç, Kadir and Yeni̇lmez, Evrim and Demi̇rel, Müzeyyen and Başaran, Ebru} }
APA Aykaç, K , Yeni̇lmez, E , Demi̇rel, M , Başaran, E . (2020). Posaconazole loaded ocular inserts for antifungal activity . Journal of Pharmaceutical Technology , 1 (1) , 1-6 . DOI: 10.37662/jpt.2020.0
MLA Aykaç, K , Yeni̇lmez, E , Demi̇rel, M , Başaran, E . "Posaconazole loaded ocular inserts for antifungal activity" . Journal of Pharmaceutical Technology 1 (2020 ): 1-6 <https://dergipark.org.tr/tr/pub/jpharmtech/issue/54396/700080>
Chicago Aykaç, K , Yeni̇lmez, E , Demi̇rel, M , Başaran, E . "Posaconazole loaded ocular inserts for antifungal activity". Journal of Pharmaceutical Technology 1 (2020 ): 1-6
RIS TY - JOUR T1 - Posaconazole loaded ocular inserts for antifungal activity AU - Kadir Aykaç , Evrim Yeni̇lmez , Müzeyyen Demi̇rel , Ebru Başaran Y1 - 2020 PY - 2020 N1 - doi: 10.37662/jpt.2020.0 DO - 10.37662/jpt.2020.0 T2 - Journal of Pharmaceutical Technology JF - Journal JO - JOR SP - 1 EP - 6 VL - 1 IS - 1 SN - -2717-7904 M3 - doi: 10.37662/jpt.2020.0 UR - https://doi.org/10.37662/jpt.2020.0 Y2 - 2020 ER -
EndNote %0 Journal of Pharmaceutical Technology Posaconazole loaded ocular inserts for antifungal activity %A Kadir Aykaç , Evrim Yeni̇lmez , Müzeyyen Demi̇rel , Ebru Başaran %T Posaconazole loaded ocular inserts for antifungal activity %D 2020 %J Journal of Pharmaceutical Technology %P -2717-7904 %V 1 %N 1 %R doi: 10.37662/jpt.2020.0 %U 10.37662/jpt.2020.0
ISNAD Aykaç, Kadir , Yeni̇lmez, Evrim , Demi̇rel, Müzeyyen , Başaran, Ebru . "Posaconazole loaded ocular inserts for antifungal activity". Journal of Pharmaceutical Technology 1 / 1 (Nisan 2020): 1-6 . https://doi.org/10.37662/jpt.2020.0
AMA Aykaç K , Yeni̇lmez E , Demi̇rel M , Başaran E . Posaconazole loaded ocular inserts for antifungal activity. J Pharm Technol. 2020; 1(1): 1-6.
Vancouver Aykaç K , Yeni̇lmez E , Demi̇rel M , Başaran E . Posaconazole loaded ocular inserts for antifungal activity. Journal of Pharmaceutical Technology. 2020; 1(1): 1-6.