Yıl 2020, Cilt 1 , Sayı 1, Sayfalar 7 - 12 2020-04-01

Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations

Tilbe ÇEVİKELLİ [1] , Deniz ONAN [2] , Umay Merve GÜVEN [3] , Esra DEMİRTÜRK [4]


Theophylline is widely used as a bronchodilator drug in asthma and chronic obstructive lung disease because it is effective and inexpensive. Theophylline blood concentrations should be monitored since its therapeutic index is narrow, its optimum blood levels range from 10 to 20 μg/mL; its serious side effects take place over 20 μg/mL; its efficacy falls below 10 μg/mL blood concentrations. The aim of the present study is to formulate and characterize oil-in-water microemulsion systems for oral delivery of theophylline. Microemulsion formulations represent an interesting delivery vehicle for poorly water-soluble drugs, allowing for improving their solubility and dissolution properties. A simple and reliable UV-Spectrophotometric method was developed and validated for the determination of theophylline in the concentration range of 25- 150 μg/mL. In vitro drug release profile showed that after 1 hour, 40% of the drug released through the formulation in Simulated Intestinal Fluid at pH 6.8 as a release medium and the microemulsion formulations released more than 75% of the drug during the 5 hours study period. The globule size of drug-loaded formulations was in the range of 203.6 ± 0.2 nm. Results confirmed that the proposed microemulsion formulation containing theophylline could improve and control the drug release profile in comparison to the conventional dosage form.
Asthma Therapy, Controlled Release, Drug Delivery System, Microemulsion, Theophylline
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Birincil Dil en
Konular Farmakoloji ve Eczacılık
Bölüm Research Articles
Yazarlar

Orcid: 0000-0002-0881-0644
Yazar: Tilbe ÇEVİKELLİ
Kurum: FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0002-4451-2687
Yazar: Deniz ONAN
Kurum: FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0003-1547-0817
Yazar: Umay Merve GÜVEN
Kurum: FACULTY OF PHARMACY
Ülke: Turkey


Orcid: 0000-0002-8918-0073
Yazar: Esra DEMİRTÜRK (Sorumlu Yazar)
Kurum: Çukurova University, Faculty of Pharmacy
Ülke: Turkey


Tarihler

Başvuru Tarihi : 8 Mayıs 2020
Kabul Tarihi : 28 Mayıs 2020
Yayımlanma Tarihi : 1 Nisan 2020

Bibtex @araştırma makalesi { jpharmtech734296, journal = {Journal of Pharmaceutical Technology}, issn = {}, eissn = {2717-7904}, address = {Anadolu Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Abd Tepebaşı Eskişehir}, publisher = {Mustafa Sinan KAYNAK}, year = {2020}, volume = {1}, pages = {7 - 12}, doi = {10.37662/jpt.2020.1}, title = {Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations}, key = {cite}, author = {Çevi̇kelli̇, Tilbe and Onan, Deniz and Güven, Umay Merve and Demi̇rtürk, Esra} }
APA Çevi̇kelli̇, T , Onan, D , Güven, U , Demi̇rtürk, E . (2020). Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations . Journal of Pharmaceutical Technology , 1 (1) , 7-12 . DOI: 10.37662/jpt.2020.1
MLA Çevi̇kelli̇, T , Onan, D , Güven, U , Demi̇rtürk, E . "Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations" . Journal of Pharmaceutical Technology 1 (2020 ): 7-12 <https://dergipark.org.tr/tr/pub/jpharmtech/issue/54396/734296>
Chicago Çevi̇kelli̇, T , Onan, D , Güven, U , Demi̇rtürk, E . "Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations". Journal of Pharmaceutical Technology 1 (2020 ): 7-12
RIS TY - JOUR T1 - Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations AU - Tilbe Çevi̇kelli̇ , Deniz Onan , Umay Merve Güven , Esra Demi̇rtürk Y1 - 2020 PY - 2020 N1 - doi: 10.37662/jpt.2020.1 DO - 10.37662/jpt.2020.1 T2 - Journal of Pharmaceutical Technology JF - Journal JO - JOR SP - 7 EP - 12 VL - 1 IS - 1 SN - -2717-7904 M3 - doi: 10.37662/jpt.2020.1 UR - https://doi.org/10.37662/jpt.2020.1 Y2 - 2020 ER -
EndNote %0 Journal of Pharmaceutical Technology Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations %A Tilbe Çevi̇kelli̇ , Deniz Onan , Umay Merve Güven , Esra Demi̇rtürk %T Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations %D 2020 %J Journal of Pharmaceutical Technology %P -2717-7904 %V 1 %N 1 %R doi: 10.37662/jpt.2020.1 %U 10.37662/jpt.2020.1
ISNAD Çevi̇kelli̇, Tilbe , Onan, Deniz , Güven, Umay Merve , Demi̇rtürk, Esra . "Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations". Journal of Pharmaceutical Technology 1 / 1 (Nisan 2020): 7-12 . https://doi.org/10.37662/jpt.2020.1
AMA Çevi̇kelli̇ T , Onan D , Güven U , Demi̇rtürk E . Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations. J Pharm Technol. 2020; 1(1): 7-12.
Vancouver Çevi̇kelli̇ T , Onan D , Güven U , Demi̇rtürk E . Preparation, characterization and in-vitro evaluation of theophylline loaded microemulsion formulations. Journal of Pharmaceutical Technology. 2020; 1(1): 7-12.