The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum

Serhat Keser; Mehmet Çelik; Güldeniz Şekerci; Suat Tekin; Omer Kaygili

doi:10.54565/jphcfum.1782528

The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum

Abstract

The genus Geranium, which is important from a medical point of view and whose leaves and tubers are consumed as food, is represented by approximately 400 species distributed especially in temperate regions around the world. One of these species is Geranium tuberosum subsp. tuberosum, a perennial herbaceous species known in our country as “turnagagası” or “devetabanı”. In this study, antiradical, anticancer and phytochemical properties of water, ethanol and methanol extracts of flowers of Geranium tuberosum subsp. tuberosum plant growing in Elazığ were investigated. In vitro antiradical assays were determined against ABTS, DPPH and OH radicals, in vitro anticancer assays were determined against A2780 human ovary, LNCaP human prostate, MCF-7 human breast and Caco-2 human colon cancer cell lines. In addition, the amounts of free fatty acids, fat-soluble vitamins, phytosterols, total phenolics, total flavonoids and total proanthocyanidins contained in this plant were also determined. At the end of the study, it was determined that all extracts of Geranium tuberosum subsp. tuberosum showed lower antiradical properties than the standard antioxidant Trolox in ABTS, DPPH and OH radical scavenging tests. In addition, it was determined that this plant is rich in total phenolics, flavonoids, proanthocyanidins, tocopherols, vitamins D and K, phytosterols and unsaturated fatty acids. According to in vitro anticancer property results, G. tuberosum methanol extracts had the highest anticancer activity against A2780 cell line, and G. tuberosum ethanol extracts had the highest anticancer activity against MCF-7, LNCaP and Caco-2 cell lines.

Keywords

References

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Serhat Keser ^*
0000-0002-9678-1053
Türkiye

Mehmet Çelik
0009-0008-8451-7651
Türkiye

Güldeniz Şekerci
0000-0002-0811-4454
Türkiye

Suat Tekin
0000-0002-2757-1802
Türkiye

Omer Kaygili
0000-0002-2321-1455
Türkiye

Publication Date

December 23, 2025

Submission Date

September 11, 2025

Acceptance Date

October 21, 2025

Published in Issue

Year 2025 Volume: 8 Number: 2

DOI

https://doi.org/10.54565/jphcfum.1782528

IZ

https://izlik.org/JA62DW84WA

Cite

RIS / Bibtex

APA

Keser, S., Çelik, M., Şekerci, G., Tekin, S., & Kaygili, O. (2025). The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum. Journal of Physical Chemistry and Functional Materials, 8(2), 184-189. https://doi.org/10.54565/jphcfum.1782528

AMA

1.Keser S, Çelik M, Şekerci G, Tekin S, Kaygili O. The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum. Journal of Physical Chemistry and Functional Materials. 2025;8(2):184-189. doi:10.54565/jphcfum.1782528

Chicago

Keser, Serhat, Mehmet Çelik, Güldeniz Şekerci, Suat Tekin, and Omer Kaygili. 2025. “The Antiradical, Phytochemical Properties and in Vitro Cytotoxic Activities of Geranium Tuberosum Subsp. Tuberosum”. Journal of Physical Chemistry and Functional Materials 8 (2): 184-89. https://doi.org/10.54565/jphcfum.1782528.

EndNote

Keser S, Çelik M, Şekerci G, Tekin S, Kaygili O (December 1, 2025) The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum. Journal of Physical Chemistry and Functional Materials 8 2 184–189.

IEEE

[1]S. Keser, M. Çelik, G. Şekerci, S. Tekin, and O. Kaygili, “The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum”, Journal of Physical Chemistry and Functional Materials, vol. 8, no. 2, pp. 184–189, Dec. 2025, doi: 10.54565/jphcfum.1782528.

ISNAD

Keser, Serhat - Çelik, Mehmet - Şekerci, Güldeniz - Tekin, Suat - Kaygili, Omer. “The Antiradical, Phytochemical Properties and in Vitro Cytotoxic Activities of Geranium Tuberosum Subsp. Tuberosum”. Journal of Physical Chemistry and Functional Materials 8/2 (December 1, 2025): 184-189. https://doi.org/10.54565/jphcfum.1782528.

JAMA

1.Keser S, Çelik M, Şekerci G, Tekin S, Kaygili O. The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum. Journal of Physical Chemistry and Functional Materials. 2025;8:184–189.

MLA

Keser, Serhat, et al. “The Antiradical, Phytochemical Properties and in Vitro Cytotoxic Activities of Geranium Tuberosum Subsp. Tuberosum”. Journal of Physical Chemistry and Functional Materials, vol. 8, no. 2, Dec. 2025, pp. 184-9, doi:10.54565/jphcfum.1782528.

Vancouver

1.Serhat Keser, Mehmet Çelik, Güldeniz Şekerci, Suat Tekin, Omer Kaygili. The antiradical, phytochemical properties and in vitro cytotoxic activities of Geranium tuberosum subsp. tuberosum. Journal of Physical Chemistry and Functional Materials. 2025 Dec. 1;8(2):184-9. doi:10.54565/jphcfum.1782528