Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice

Soni Andriawan; Hany Handajani; Ahmad Shobrun Jamil

doi:10.12991/jrespharm.1638350

Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice

Abstract

This study explores the antihyperglycemic and antihypercholesterolemic potential of Skeletonema costatum, a marine microalga, in diabetic and hypercholesterolemic mice models. The study compared the effects of S. costatum in infusion (SCI) and powder (SCP) forms at two concentrations (2.5% and 5%) with standard treatments, including glibenclamide for diabetes and simvastatin for hypercholesterolemia, as well as a no-treatment control. Over 21 days, SCP demonstrated significant and sustained reductions in both blood glucose and cholesterol levels, with the 2.5% SCP dose outperforming the 5% dose. SCI showed transient effects, with initial reductions in glucose and cholesterol levels followed by rebounds, likely due to the rapid metabolism of bioactive compounds. The powdered form's superior efficacy is attributed to its slower digestion and gradual release of omega-3 fatty acids, polyphenols, and bioactive peptides, which improve insulin sensitivity, reduce oxidative stress, and regulate lipid metabolism. Simvastatin showed the most pronounced cholesterol-lowering effect, confirming its efficacy as a standard therapy. The study underscores the potential of S. costatum, particularly SCP, as a natural alternative or complementary therapy for managing diabetes and hypercholesterolemia. Future investigations should optimize dosing, explore its synergistic effects with conventional treatments, and evaluate its long-term safety and therapeutic potential in humans.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology, Basic Pharmacology

Journal Section

Research Article

Authors

Soni Andriawan ^*
0000-0001-7835-1781
Indonesia

Hany Handajani This is me
0000-0001-5787-7346
Indonesia

Ahmad Shobrun Jamil This is me
0000-0001-9903-0055
Indonesia

Publication Date

March 15, 2026

Submission Date

February 12, 2025

Acceptance Date

June 12, 2025

Published in Issue

Year 2026 Volume: 30 Number: 2

DOI

https://doi.org/10.12991/jrespharm.1638350

IZ

https://izlik.org/JA85DW92WL

Cite

RIS / Bibtex

APA

Andriawan, S., Handajani, H., & Jamil, A. S. (2026). Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice. Journal of Research in Pharmacy, 30(2), 367-380. https://doi.org/10.12991/jrespharm.1638350

AMA

1.Andriawan S, Handajani H, Jamil AS. Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice. J. Res. Pharm. 2026;30(2):367-380. doi:10.12991/jrespharm.1638350

Chicago

Andriawan, Soni, Hany Handajani, and Ahmad Shobrun Jamil. 2026. “Exploring the Potential of Skeletonema Costatum, Natural Shrimp Feed As an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice”. Journal of Research in Pharmacy 30 (2): 367-80. https://doi.org/10.12991/jrespharm.1638350.

EndNote

Andriawan S, Handajani H, Jamil AS (March 1, 2026) Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice. Journal of Research in Pharmacy 30 2 367–380.

IEEE

[1]S. Andriawan, H. Handajani, and A. S. Jamil, “Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice”, J. Res. Pharm., vol. 30, no. 2, pp. 367–380, Mar. 2026, doi: 10.12991/jrespharm.1638350.

ISNAD

Andriawan, Soni - Handajani, Hany - Jamil, Ahmad Shobrun. “Exploring the Potential of Skeletonema Costatum, Natural Shrimp Feed As an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice”. Journal of Research in Pharmacy 30/2 (March 1, 2026): 367-380. https://doi.org/10.12991/jrespharm.1638350.

JAMA

1.Andriawan S, Handajani H, Jamil AS. Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice. J. Res. Pharm. 2026;30:367–380.

MLA

Andriawan, Soni, et al. “Exploring the Potential of Skeletonema Costatum, Natural Shrimp Feed As an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice”. Journal of Research in Pharmacy, vol. 30, no. 2, Mar. 2026, pp. 367-80, doi:10.12991/jrespharm.1638350.

Vancouver

1.Soni Andriawan, Hany Handajani, Ahmad Shobrun Jamil. Exploring the Potential of Skeletonema costatum, natural shrimp feed as an Antihyperglycemic and Antihypercholesterolemic Therapy for Diabetes Mellitus in Mice. J. Res. Pharm. 2026 Mar. 1;30(2):367-80. doi:10.12991/jrespharm.1638350