Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy

Vella Lailli Damarwati; Fairuz Rizkika Widiaswara; Fajriah Khoiratunisa; Risa Umari Yuli Aliviyanti; Dyah Rahmasari; Aji Winanta

doi:10.12991/jrespharm.1650089

Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy

Abstract

Essential oils contain terpenoid and non-terpenoid compounds that have antioxidant activity. Antioxidants have been widely researched to be developed in health and cosmetics. This study aims to determine the antioxidant activity of Vetiveria zizaniodes essential oil formulated as nanocream. Extraction was prepared by steam distillation method. The nanocream preparation was made into three variants of essential oil concentration, namely FI (1%), F2 (3%), and F3 (5%) v/v. Each formula was tested for physical characteristics, including organoleptic, homogeneity, spread ability, Ph, viscosity, particle size, stability, and antioxidant activity. Data were analyzed using the statistical analysis methods. The results showed that the nanocream preparation produced had good physical characteristics according to the requirements. F1 has a smaller particle size (133.5 nm) than the other formulas. The IC50 values produced for F1 (41.63 ± 0.58), F2 (22.68 ± 0.19), and F3 (12.31 ± 0.78), clasifiying into extremely strong. FIII is an optimal formulation based on physical characteristics and antioxidant efficacy.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Vella Lailli Damarwati ^*
0000-0002-3198-4028
Indonesia

Fairuz Rizkika Widiaswara This is me
0009-0009-3258-5916
Indonesia

Fajriah Khoiratunisa This is me
0009-0009-8385-2922
Indonesia

Risa Umari Yuli Aliviyanti This is me
0009-0002-6868-3699
Indonesia

Dyah Rahmasari This is me
0000-0002-2771-9985
Indonesia

Aji Winanta This is me
0000-0002-2700-7873
Indonesia

Publication Date

March 15, 2026

Submission Date

March 3, 2025

Acceptance Date

June 12, 2025

Published in Issue

Year 2026 Volume: 30 Number: 2

DOI

https://doi.org/10.12991/jrespharm.1650089

IZ

https://izlik.org/JA64ZE34SY

Cite

RIS / Bibtex

APA

Lailli Damarwati, V., Widiaswara, F. R., Khoiratunisa, F., Aliviyanti, R. U. Y., Rahmasari, D., & Winanta, A. (2026). Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy. Journal of Research in Pharmacy, 30(2), 417-426. https://doi.org/10.12991/jrespharm.1650089

AMA

1.Lailli Damarwati V, Widiaswara FR, Khoiratunisa F, Aliviyanti RUY, Rahmasari D, Winanta A. Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy. J. Res. Pharm. 2026;30(2):417-426. doi:10.12991/jrespharm.1650089

Chicago

Lailli Damarwati, Vella, Fairuz Rizkika Widiaswara, Fajriah Khoiratunisa, Risa Umari Yuli Aliviyanti, Dyah Rahmasari, and Aji Winanta. 2026. “Vetiver Root (Vetiveria Zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy”. Journal of Research in Pharmacy 30 (2): 417-26. https://doi.org/10.12991/jrespharm.1650089.

EndNote

Lailli Damarwati V, Widiaswara FR, Khoiratunisa F, Aliviyanti RUY, Rahmasari D, Winanta A (March 1, 2026) Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy. Journal of Research in Pharmacy 30 2 417–426.

IEEE

[1]V. Lailli Damarwati, F. R. Widiaswara, F. Khoiratunisa, R. U. Y. Aliviyanti, D. Rahmasari, and A. Winanta, “Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy”, J. Res. Pharm., vol. 30, no. 2, pp. 417–426, Mar. 2026, doi: 10.12991/jrespharm.1650089.

ISNAD

Lailli Damarwati, Vella - Widiaswara, Fairuz Rizkika - Khoiratunisa, Fajriah - Aliviyanti, Risa Umari Yuli - Rahmasari, Dyah - Winanta, Aji. “Vetiver Root (Vetiveria Zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy”. Journal of Research in Pharmacy 30/2 (March 1, 2026): 417-426. https://doi.org/10.12991/jrespharm.1650089.

JAMA

1.Lailli Damarwati V, Widiaswara FR, Khoiratunisa F, Aliviyanti RUY, Rahmasari D, Winanta A. Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy. J. Res. Pharm. 2026;30:417–426.

MLA

Lailli Damarwati, Vella, et al. “Vetiver Root (Vetiveria Zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy”. Journal of Research in Pharmacy, vol. 30, no. 2, Mar. 2026, pp. 417-26, doi:10.12991/jrespharm.1650089.

Vancouver

1.Vella Lailli Damarwati, Fairuz Rizkika Widiaswara, Fajriah Khoiratunisa, Risa Umari Yuli Aliviyanti, Dyah Rahmasari, Aji Winanta. Vetiver Root (Vetiveria zizanioides) Essential Oil Nanocream for Topical Delivery: Development, Characterization and Antioxidant Efficacy. J. Res. Pharm. 2026 Mar. 1;30(2):417-26. doi:10.12991/jrespharm.1650089