Magnesium citrate: potential and current approaches in pharmacy

Year 2026, Volume: 30 Issue: 1, 117 - 125, 11.01.2026

Özge Demir , Oya Kerimoğlu , Kübra Elçioğlu

https://doi.org/10.12991/jrespharm.1654713

Abstract

Magnesium, the fourth most abundant cation in the human body and the second most abundant intracellular cation after potassium, is an essential mineral. Therefore, magnesium deficiency can lead to various symptoms and manifestations in the body. Today, to address magnesium deficiency, various dosage forms (powder, tablet, capsule, sachet, lozenge, etc.) are available on the market. These dosage forms contain different forms of magnesium. Among them, magnesium citrate is the most extensively researched and most frequently used form by individuals. To date, numerous studies have been conducted in the literature on magnesium citrate. This review presents information about magnesium citrate and summarizes various studies conducted on this topic.

Keywords

Magnesium , Forms of magnesium , Magnesium citrate , Magnesium in pharmacy

References

• [1] Jahnen-Dechent W, Ketteler M. Magnesium basics. Clinical Kidney Journal. 2012; 5(Suppl_1): i3-i14. https://doi.org/10.1093/ndtplus/sfr163.
• [2] Luft FC. Whither magnesium?. Clinical Kidney Journal. 2012; 5(Suppl_1): i1-i2. https://doi.org/10.1093/ndtplus/sfr162.
• [3] Swaminathan R. Magnesium metabolism and its disorders. The Clinical Biochemist Reviews. 2003; 24(2): 47.
• [4] Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 2003; 24(1-3): 27-37. https://doi.org/10.1016/S0098-2997(02)00089-4.
• [5] Hruby A, McKeown NM. Magnesium deficiency: what is our status?. Nutrition Today. 2016; 51(3): 121-128.
• [6] Ranade VV, Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. American Journal of Therapeutics. 2001; 8(5): 345-357. https://doi.org/10.1097/00045391-200109000-00008.
• [7] Pardo MR, Vilar EG, Martín ISM, Martín MAC. Bioavailability of magnesium food supplements: A systematic review. Nutrition. 2021; 89 111294. https://doi.org/10.1016/j.nut.2021.111294.
• [8] Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015; 7(9): 8199-8226. https://doi.org/10.3390/nu7095388.
• [9] Morel V, Pickering ME, Goubayon J, Djobo M, Macian N, Pickering G. Magnesium for pain treatment in 2021? State of the art. Nutrients. 2021; 13(5): 1397. https://doi.org/10.3390/nu13051397.
• [10] Türkoğlu M. Tabletler. In: Zırh Gürsoy A. (Ed). Farmasötik Teknoloji: Temel Konular ve Dozaj Şekilleri, second ed., Istanbul, 2004, pp.349–361.
• [11] Acartürk F. Sert ve yumuşak kapsüller. In: Zırh Gürsoy A. (Ed). Farmasötik Teknoloji: Temel Konular ve Dozaj Şekilleri, second ed., İstanbul, 2004, pp.331–346.
• [12] Baykara T. Tozlar, granüller, mikropelletler. In: Zırh Gürsoy A. (Ed). Farmasötik Teknoloji: Temel Konular ve Dozaj Şekilleri, second ed., İstanbul, 2004, pp.313–327.
• [13] Yücel K, Bölüm 5. Güncel Biyokimya Çalışmaları III, 2022.
• [14] Schutten JC, Joris PJ, Groendijk I, Eelderink C, Groothof D, van der Veen Y, Bakker SJ. Effects of magnesium citrate, magnesium oxide, and magnesium sulfate supplementation on arterial stiffness: a randomized, double‐blind, placebo‐controlled intervention trial. Journal of the American Heart Association. 2022; 11(6), e021783. https://doi.org/10.1161/JAHA.121.021783.
• [15] Fathi N, Hosseini S, Tavakkol H, Khodadady A, Tabesh H. Effect of oral magnesium citrate supplement on lung function and magnesium level in patients with asthma. Journal of Mazandaran University of Medical Sciences. 2014; 24(111): 44-51.
• [16] Lindberg JS, Zobitz MM, Poindexter JR, Pak CY. Magnesium bioavailability from magnesium citrate and magnesium oxide. Journal of the American College of Nutrition. 1990; 9(1): 48-55. https://doi.org/10.1080/07315724.1990.10720349.
• [17] Ates M, Kızıldağ S, Yüksel O, Hoşgörler F, Yüce Z, Güvendi G, Uysal N. Dose-dependent absorption profile of different magnesium compounds. Biological Trace Element Research. 2019; 192, 244-251. 10.1007/s12011-019-01663-0. [18] Nielsen FH, Johnson LK, Zeng, H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium Research. 2010; 23(4), 158-168. 10.1684/mrh.2010.0220.
• [19] Bagis S, Karabiber M, As I, Tamer L, Erdogan C, Atalay A. Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?. Rheumatology International. 2013; 33, 167-172. 10.1007/s00296-011-2334-8.
• [20] Alghadeer S. The efficacy of different oral magnesium supplements for migraine prevention: a literature review. Indonesian Journal of Pharmacy. 2016; 27(3), 174. [21] Araújo CALD, Lorena SBD, Cavalcanti GCDS, Leão GLDS, Tenório GP, Alves JGB. Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial. PLoS One. 2020; 15(1), e0227497. https://doi.org/10.1371/journal.pone.0227497.
• [22] Alves JGB, de Araújo CAFL, Pontes IE, Guimarães AC, Ray JG. The B RAzil MAG nesium (BRAMAG) trial: a randomized clinical trial of oral magnesium supplementation in pregnancy for the prevention of preterm birth and perinatal and maternal morbidity. BMC Pregnancy and Childbirth. 2014; 14, 1-8. 10.1186/1471-2393-14-222.
• [23] Bullarbo M, Ödman N, Nestler A, Nielsen T, Kolisek M, Vormann J, Rylander R. Magnesium supplementation to prevent high blood pressure in pregnancy: a randomised placebo control trial. Archives of Gynecology and Obstetrics. 2013; 288, 1269-1274. 10.1007/s00404-013-2900-2.
• [24] Shatynska O, Tokarskyy O, Lykhatskyi P, Yaremchuk O, Bandas I, Mashtalir A. Dietary supplementation with magnesium citrate may improve pancreatic metabolic indices in an alloxan-induced diabetes rat model. Slovak Journal of Food Sciences. 2020; 14. [25] Zanforlini BM, Ceolin C, Trevisan C, Alessi A, Seccia DM, Noale M, Sergi G. Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients. Aging Clinical and Experimental Research. 2022; 1-8. https://doi.org/10.1007/s40520-021-01921-z.
• [26] Aydın H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalın S. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biological Trace Element Research. 2010; 133, 136-143. 10.1007/s12011-009-8416-8.
• [27] Eidensohn Y, Mond Y, Labowitz I, Greenberg P, Formanowski B, Eidensohn C, Dubin E. Magnesium citrate capsules in colonoscopy preparation: a randomized controlled trial. Cureus. 2021; 13(12). 10.7759/cureus.20506.
• [28] Bayram S, Şahin K, Anarat FB, Chousein CM, Kocazeybek E, Altan M, Akgül T. The effect of oral magnesium supplementation on acute non-specific low back pain: Prospective randomized clinical trial. The American Journal of Emergency Medicine. 2021; 47, 125-130. https://doi.org/10.1016/j.ajem.2021.03.078. [29] Tarsitano MG, Quinzi F, Folino K, Greco F, Oranges FP, Cerulli C, Emerenziani GP. Effects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review. Journal of Translational Medicine. 2024; 22(1), 629. 10.1186/s12967-024-05434-x.
• [30] Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, Taheri F. Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Magnesium Research. 2024; 37(1). 10.1684/mrh.2024.0524.
• [31] Digdoyo A, Pinzon RT, Pramudita EA. Effectiveness of magnesium citrate adjunctive therapy on cramping pain intensity in nocturnal leg cramps patients at bethesda Hospital Yogyakarta. Jurnal Farmasi Sains Dan Praktis. 2024; 61-69. [32] Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, Wang YA. Magtein®, magnesium L-Threonate,-based formula improves brain cognitive functions in healthy Chinese adults. Nutrients. 2022; 14(24), 5235. https://doi.org/10.3390/nu14245235.
• [33] Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Medical Hypotheses. 2006; 67(2), 362-370. https://doi.org/10.1016/j.mehy.2006.01.047.
• [34] Schille LR. The therapy of constipation. Alimentary Pharmacology & Therapeutics. 2001; 15(6), 749-763. https://doi.org/10.1046/j.1365-2036.2001.00982.x. [35] Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2002; 8(5), CR326-30. [36] Zerwekh JE, Odvina CV, Wuermser LA, Pak CY. Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest. The Journal of Urology. 2007; 177(6), 2179-2184. https://doi.org/10.1016/j.juro.2007.01.156.
• [37] Porri D, Biesalski HK, Limitone A, Bertuzzo L, Cena H. Effect of magnesium supplementation on women's health and well-being. NFS Journal. 2021; 23, 30-36.
• [38] Lamontagne C, Sewell JA, Vaillancourt R, Kuhzarani C. Rapid resolution of chronic back pain with magnesium glycinate in a pediatric patient. J Pain Relief. 2012; 1(101), 2.
• [39] Kisters K, Werner T, Tokmak F, Predel HG, Reuter H, Kisters S. Magnesium supplementation reduces inerleukin-6 and blood pressure in metabolic syndrome. Journal of Hypertension. 2024; 42(Suppl 1), e227.
• [40] Gorantla S, Ravisankar A, Trotti LM. Magnesium citrate monotherapy improves RLS symptoms and multiple suggested immobilization test scores in an open-label pilot study. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine. 2024. https://doi.org/10.5664/jcsm.11206.
• [41] Panta R, Regmi S. Role of magnesium, effects of hypomagnesemia, and benefits of magnesium supplements in cardiovascular and chronic kidney diseases. Cureus. 2024; 16(7). 10.7759/cureus.64404.
• [42] Rajanna H, Chaudhry K, Pandey AK, Somvanshi S, Singh S, Kumar P, Chugh A. Efficacy of oral magnesium on bone regeneration and implant stability in immediate dental implants: A randomized controlled trial. The International Journal of Oral & Maxillofacial Implants. 2024; 1-31. 10.11607/jomi.11017. [43] Rukat M, Przyborowska K, Kwiecień J, Getka B, Wiejak K, Łata M. The relationship between magnesium deficiency and anxiety, the therapeutic effects of magnesium supplementation–literature review. Journal of Education, Health and Sport. 2024; 53, 91-101.
• [44] De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiological Reviews. 2015. https://doi.org/10.1152/physrev.00012.2014.
• [45] Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. Journal of Parenteral and Enteral Nutrition. 1994; 18(5), 430-435. https://doi.org/10.1177/0148607194018005430.
• [46] Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnesium Research. 2003; 16(3), 183-191. https://pubmed.ncbi.nlm.nih.gov/14596323/.
• [47] Cao Y, Zhen S, Taylor AW, Appleton S, Atlantis E, Shi Z. Magnesium intake and sleep disorder symptoms: evidence from a Chinese population study. Nutrients. 2018; 10(9), 1200. https://doi.org/10.3390/nu10091200.
• [48] Rosique-Esteban N, Guasch-Ferré M, Hernández-Alonso P, Salas-Salvadó J. Dietary magnesium and cardiovascular disease: a review with emphasis in epidemiological studies. Nutrients. 2018; 10(2), 168. https://doi.org/10.3390/nu10020168.
• [49] Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutrition Reviews. 2012; 70(3), 153-164. https://doi.org/10.1111/j.1753-4887.2011.00465.x.
• [50] DiNicolantonio JJ, O'Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018; 5(1), e000668. https://doi.org/10.1136/openhrt-2017-000668.
• [51] Musso CG. Magnesium metabolism in health and disease. International Urology and Nephrology. 2009; 41(2), 357-362. https://doi.org/10.1007/s11255-008-9480-9.