Pharmacological, medicinal and biological properties of flavonoids: A comprehensive review

Abstract

Plant-based phytochemicals are currently being used to prevent and treat several diseases. Flavonoids are plant-based compounds that are widely found in the plant kingdom, which contain the benzopyrone ring, and possess various biological activities. To date, approximately more than 6000 different flavonoids have been identified and classified as flavones, flavanones, flavanols, isoflavones, anthocyanidins, and catechins. Many in vitro and in vivo experimental studies were published on the use of flavonoids in different conditions. Antioxidant, antiinflammatory, antibacterial, antifungal, antiviral, antihypertensive, antihyperlipidemic, antithrombotic, antiasthma, antiallergic, antidiabetic, antiobesity, antiarthritis, antiulcer, hepatoprotective, osteoprotective, immunomodulation, anticancer, antiaging, neuroprotective, antiaddictive, antiparkinsonian, antiepileptic, anxiolytics and antidepressant are among the primary pharmacological properties of these compounds. Despite a wide range of the ongoing research on the potential health benefits of flavonoids, the U.S. FDA (and similar organizations) has not approved any flavonoid compounds for therapeutic use. However, these compounds are available as nutritional supplements in various dosage forms. In this review, we used the databases like PubMed, Web of Science, ScienceDirect, Scopus, ResearchGate and Google Scholar to find the best-matched information about flavonoids’ pharmacological, medicinal and biological properties to elucidate the therapeutic potential as well as their side effects. A comprehensive systematic literature review was carried out to achieve the main goal of this study.

Keywords

• Flavonoids
• polyphenols
• pharmacological activity
• therapeutic potential
• systematic review

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