Velvet bean (Mucuna pruriens L. (DC.)) leaf ointment: candidate for standardized natural anti-inflammatory drug ingredients based on local wisdom

Year 2026, Volume: 30 Issue: 2 , 553 - 568 , 15.03.2026

Fadilaturahmah Fadilaturahmah , Resti Rahayu , Putra Santoso

https://doi.org/10.12991/jrespharm.1677318

https://izlik.org/JA69WD49YK

Abstract

Skin inflammation is a serious problem that must be addressed. The use of steroid and non-steroid drugs is effective as an anti-inflammatory but has many side effects. One of the natural ingredients used by the community as an anti-inflammatory is the leaves of the velvet bean (Mucuna pruriens L. (DC.)). This study aims to prove that velvet bean leaf ointment is effective as an anti-inflammatory, which is indicated by improvements in the morphology and structure of the skin tissue of mice experiencing inflammation. The research method is an experiment with a completely randomized design consisting of 6 treatments with five replications (normal, negative control, positive control, and velvet bean leaf ointment at 200, 400, and 600 mg/kgBW). Quantitative data were analyzed using Duncan's Multiple Range Test. The results showed that the use of ointments of 200 and 400 mg/kgBW was able to improve the morphology of the skin of mice experiencing inflammation, which was indicated by a significant decrease in the thickness of the back folds (P <0.05) and had the highest anti-inflammatory power of 35.77%. In addition, 200 mg/kg BW ointment improved the histological structure of the inflamed mouse skin tissue because it significantly reduced the dermis layer's thickness and the number of inflammatory cells in the dermis layer (P<0.05). Therefore, the velvet bean leaf ointment has great potential to be developed into a standardized anti-inflammatory drug because it effectively improves the morphology and histological structure of the inflamed mouse skin tissue.

Keywords

Dermis , Histological , Ketoconazole , Ointment , Skin

Ethical Statement

All procedures and treatments of test animals were carried out based on the approval of the Andalas University Research Ethics Committee (No.612/UN.16.2/KEP-FK/2022).

Supporting Institution

Thank you to Universitas Negeri Padang and Universitas Andalas for facilitating the implementation of this research.

Project Number

Contract No. 086/E5/PG.02.00.PT/2022; PIC Dr. Putra Santoso

Thanks

Thank you to the Ministry of Education, Culture, Research, and Technology for the funds provided for research through the National Competitive Program, namely the Postgraduate Research Scheme Master Thesis Research

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