Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

Gözde Ultav; Hayrettin Tonbul; Adem Şahin; Yılmaz Çapan

Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

Abstract

Silica nanoparticles (SNPs) are one of the most researched drug/gene delivery platforms due to their easy and cheap production. Their toxicity depends on the nanoparticle characteristics like particle size or shape. It is well known that the smaller nanoparticles have a better cellular uptake potential. For this reason, in this study, we synthesized SNPs with a particle size of around 100 nm via an experimental design method that combines Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) with Taguchi design to optimize more than one response. After the optimization, average particle size, particle size distribution, zeta potential, and particle morphology of validated SNPs were analyzed. The cytotoxicity studies were performed on fibroblast cells (L929) for 48 and 72 hours. Results show that obtained nanoparticles were spherical-shaped with a size of around 100 nm and had good biocompatibility.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Gözde Ultav ^* This is me
0000-0001-5582-3766
Türkiye

Hayrettin Tonbul
0000-0001-5510-8973
Türkiye

Adem Şahin
0000-0002-3996-2931
Türkiye

Yılmaz Çapan
0000-0003-1234-9018
Türkiye

Publication Date

June 28, 2025

Submission Date

May 29, 2022

Acceptance Date

August 12, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA83PB69CB

Cite

RIS / Bibtex

APA

Ultav, G., Tonbul, H., Şahin, A., & Çapan, Y. (2025). Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of Research in Pharmacy, 27(1), 12-22. https://izlik.org/JA83PB69CB

AMA

1.Ultav G, Tonbul H, Şahin A, Çapan Y. Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. J. Res. Pharm. 2025;27(1):12-22. https://izlik.org/JA83PB69CB

Chicago

Ultav, Gözde, Hayrettin Tonbul, Adem Şahin, and Yılmaz Çapan. 2025. “Silica Nanoparticle Synthesis by Experimental Design for Drug and Gene Delivery Applications”. Journal of Research in Pharmacy 27 (1): 12-22. https://izlik.org/JA83PB69CB.

EndNote

Ultav G, Tonbul H, Şahin A, Çapan Y (June 1, 2025) Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of Research in Pharmacy 27 1 12–22.

IEEE

[1]G. Ultav, H. Tonbul, A. Şahin, and Y. Çapan, “Silica nanoparticle synthesis by experimental design for drug and gene delivery applications”, J. Res. Pharm., vol. 27, no. 1, pp. 12–22, June 2025, [Online]. Available: https://izlik.org/JA83PB69CB

ISNAD

Ultav, Gözde - Tonbul, Hayrettin - Şahin, Adem - Çapan, Yılmaz. “Silica Nanoparticle Synthesis by Experimental Design for Drug and Gene Delivery Applications”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 12-22. https://izlik.org/JA83PB69CB.

JAMA

1.Ultav G, Tonbul H, Şahin A, Çapan Y. Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. J. Res. Pharm. 2025;27:12–22.

MLA

Ultav, Gözde, et al. “Silica Nanoparticle Synthesis by Experimental Design for Drug and Gene Delivery Applications”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 12-22, https://izlik.org/JA83PB69CB.

Vancouver

1.Gözde Ultav, Hayrettin Tonbul, Adem Şahin, Yılmaz Çapan. Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):12-2. Available from: https://izlik.org/JA83PB69CB