Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Fatih Tok; Elif Kaya Tilki; Miriş Dikmen; Bedia Kaymakçıoğlu

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Abstract

In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didn’t show cytotoxic effects on normal BJ cells.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Fatih Tok
Türkiye

Elif Kaya Tilki
Türkiye

Miriş Dikmen
Türkiye

Bedia Kaymakçıoğlu ^*
Türkiye

Publication Date

June 28, 2025

Submission Date

June 20, 2021

Acceptance Date

November 15, 2021

Published in Issue

Year 2022 Volume: 26 Number: 1

IZ

https://izlik.org/JA83NS49EC

Cite

RIS / Bibtex

APA

Tok, F., Kaya Tilki, E., Dikmen, M., & Kaymakçıoğlu, B. (2025). Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety. Journal of Research in Pharmacy, 26(1), 13-19. https://izlik.org/JA83NS49EC

AMA

1.Tok F, Kaya Tilki E, Dikmen M, Kaymakçıoğlu B. Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety. J. Res. Pharm. 2025;26(1):13-19. https://izlik.org/JA83NS49EC

Chicago

Tok, Fatih, Elif Kaya Tilki, Miriş Dikmen, and Bedia Kaymakçıoğlu. 2025. “Synthesis and Anticancer Activity of New Carbohydrazide Derivatives Bearing Furan Moiety”. Journal of Research in Pharmacy 26 (1): 13-19. https://izlik.org/JA83NS49EC.

EndNote

Tok F, Kaya Tilki E, Dikmen M, Kaymakçıoğlu B (June 1, 2025) Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety. Journal of Research in Pharmacy 26 1 13–19.

IEEE

[1]F. Tok, E. Kaya Tilki, M. Dikmen, and B. Kaymakçıoğlu, “Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety”, J. Res. Pharm., vol. 26, no. 1, pp. 13–19, June 2025, [Online]. Available: https://izlik.org/JA83NS49EC

ISNAD

Tok, Fatih - Kaya Tilki, Elif - Dikmen, Miriş - Kaymakçıoğlu, Bedia. “Synthesis and Anticancer Activity of New Carbohydrazide Derivatives Bearing Furan Moiety”. Journal of Research in Pharmacy 26/1 (June 1, 2025): 13-19. https://izlik.org/JA83NS49EC.

JAMA

1.Tok F, Kaya Tilki E, Dikmen M, Kaymakçıoğlu B. Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety. J. Res. Pharm. 2025;26:13–19.

MLA

Tok, Fatih, et al. “Synthesis and Anticancer Activity of New Carbohydrazide Derivatives Bearing Furan Moiety”. Journal of Research in Pharmacy, vol. 26, no. 1, June 2025, pp. 13-19, https://izlik.org/JA83NS49EC.

Vancouver

1.Fatih Tok, Elif Kaya Tilki, Miriş Dikmen, Bedia Kaymakçıoğlu. Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(1):13-9. Available from: https://izlik.org/JA83NS49EC