Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach

Dr. Abhishek Kanugo; Anushka Thanvi

Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach

Abstract

The therapeutic efficacy of an active ingredients are imperfect owing to the poor solubility and dissolution rate. Moreover, dissolution is the rate-limiting period towards the absorption and bioavailability of the active ingredients. Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) recommended for the therapy of high blood pressure as well as minimizes the chances of stroke, heart attack and kidney problems. Olmesartan medoxomil is a BCS class II molecule with only 26 % bioavailability. Hence, the current research work was focused on cost-effective Liquisolid technology for the improvement of solubility, dissolution rate and thereby achieving higher therapeutic efficacy. Liquisolid Compact is one of the best technique for improvement of solubility of potent hydrophobic molecules by utilizing non-volatile solvent. The solubility of olmesartan was estimated in several non-volatile solvents and tween 80 (95 mg/ml) was found to be best. The formed liquid medicaments were converted into the free-flowing powder blends for direct compression by the addition of carrier (Dibasic anhydrous calcium phosphate) and coating agent (Neusilin US2). The drug-excipients compatibilities were confirmed with FTIR. QbD design (Box-Behnken) was applied which comprised of independent factors (X1: DCP, X2: Neusilin US2, X3: CCS) and dependable factors were (Y1: Disintegration time, Y2: Dissolution release). The Design of expert software (DOE, Statease, Version 11) showed 12 batches which were evaluated for their flowing characteristics. The optimized batch F12 showed excellent flowing characteristics (Carr’s index: 14, Angle of repose: 24.42), rapid disintegration time (2.07 min), in-vitro drug release (99.45%) and qualify under accelerated stability testing with minimal drug loss.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Dr. Abhishek Kanugo ^*
0000-0002-5205-5906
India

Anushka Thanvi This is me
0000-0002-1852-5847
India

Publication Date

June 28, 2025

Submission Date

May 20, 2022

Acceptance Date

August 3, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA57MD83AU

Cite

RIS / Bibtex

APA

Kanugo, D. A., & Thanvi, A. (2025). Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach. Journal of Research in Pharmacy, 27(1), 52-66. https://izlik.org/JA57MD83AU

AMA

1.Kanugo DA, Thanvi A. Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach. J. Res. Pharm. 2025;27(1):52-66. https://izlik.org/JA57MD83AU

Chicago

Kanugo, Dr. Abhishek, and Anushka Thanvi. 2025. “Neusilin US2 Based Liquisolid Compact Technique for the Enhancement of Solubility and Dissolution Rate of Olmesartan: Box-Behnken Design Approach”. Journal of Research in Pharmacy 27 (1): 52-66. https://izlik.org/JA57MD83AU.

EndNote

Kanugo DA, Thanvi A (June 1, 2025) Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach. Journal of Research in Pharmacy 27 1 52–66.

IEEE

[1]D. A. Kanugo and A. Thanvi, “Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach”, J. Res. Pharm., vol. 27, no. 1, pp. 52–66, June 2025, [Online]. Available: https://izlik.org/JA57MD83AU

ISNAD

Kanugo, Dr. Abhishek - Thanvi, Anushka. “Neusilin US2 Based Liquisolid Compact Technique for the Enhancement of Solubility and Dissolution Rate of Olmesartan: Box-Behnken Design Approach”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 52-66. https://izlik.org/JA57MD83AU.

JAMA

1.Kanugo DA, Thanvi A. Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach. J. Res. Pharm. 2025;27:52–66.

MLA

Kanugo, Dr. Abhishek, and Anushka Thanvi. “Neusilin US2 Based Liquisolid Compact Technique for the Enhancement of Solubility and Dissolution Rate of Olmesartan: Box-Behnken Design Approach”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 52-66, https://izlik.org/JA57MD83AU.

Vancouver

1.Dr. Abhishek Kanugo, Anushka Thanvi. Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):52-66. Available from: https://izlik.org/JA57MD83AU