Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

Ismail Ismail; Elly Irma Sunaryo; Baharuddin Kordja; Ade Nurkhotimah; Suparta Mahmuddin

Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm

Abstract

Helminths disease is one of the infectious diseases caused by the entry of parasites in the form of worm eggs into the human body through the human digestive tract due to pollution through the soil-transmitted helminth (STH). This study measured the in vitro effect of Areca catechu ethanol extract partitioning as anthelmintic against Ascaris lumbricoides worms using a 125 mg pyrantel pamoate control. The test animals used were living and mobile worms of A. lumbricoides, which were taken from the small intestines of pigs. The study group was divided into 5 groups, namely positive control (pyrantel pamoate ) 125 mg), negative control (0.9% NaCl solution) and ethanol extract group A. catechu 10%, 20%, 30%. The results confirmed that the ethanol extract partition of A. catechu at exposure to a concentration of 30% showed a high level of efficacy in killing worms with an average time of death of A. lumbricoides worms at 6 to 12 hours compared to pyrantel pamoat solution. However, at exposure to concentration, 10% and 20% obtained a slightly longer average mortality time of 8 to 24 hours, respectively. Partitioning of A. catechu ethanol extract at a concentration of 30% showed the highest level of efficacy in killing A. lumbricoides worms based on average faster mortality time than the concentrations of 10% and 20% collected. Ethanol extract A. catechu has pharmacological therapeutic effects have various properties, including can be used for the treatment of diseases caused by parasites and also several other diseases.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences, Pharmacognosy

Journal Section

Research Article

Authors

Ismail Ismail ^*
0000-0002-6839-454X
Indonesia

Elly Irma Sunaryo This is me
0009-0008-9633-0253
Indonesia

Baharuddin Kordja This is me
0009-0005-2195-4254
Indonesia

Ade Nurkhotimah
0009-0004-6000-6559
Indonesia

Suparta Mahmuddin This is me
0000-0003-0156-8477
Indonesia

Publication Date

June 28, 2025

Submission Date

April 5, 2023

Acceptance Date

August 11, 2023

Published in Issue

Year 2024 Volume: 28 Number: 2

IZ

https://izlik.org/JA44ZU55ZY

Cite

RIS / Bibtex

APA

Ismail, I., Sunaryo, E. I., Kordja, B., Nurkhotimah, A., & Mahmuddin, S. (2025). Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm. Journal of Research in Pharmacy, 28(2), 571-578. https://izlik.org/JA44ZU55ZY

AMA

1.Ismail I, Sunaryo EI, Kordja B, Nurkhotimah A, Mahmuddin S. Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm. J. Res. Pharm. 2025;28(2):571-578. https://izlik.org/JA44ZU55ZY

Chicago

Ismail, Ismail, Elly Irma Sunaryo, Baharuddin Kordja, Ade Nurkhotimah, and Suparta Mahmuddin. 2025. “Effect in Vitro of Areca Catechu Ethanol Extract Partition As Anthelmintics Against Roundworm”. Journal of Research in Pharmacy 28 (2): 571-78. https://izlik.org/JA44ZU55ZY.

EndNote

Ismail I, Sunaryo EI, Kordja B, Nurkhotimah A, Mahmuddin S (June 1, 2025) Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm. Journal of Research in Pharmacy 28 2 571–578.

IEEE

[1]I. Ismail, E. I. Sunaryo, B. Kordja, A. Nurkhotimah, and S. Mahmuddin, “Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm”, J. Res. Pharm., vol. 28, no. 2, pp. 571–578, June 2025, [Online]. Available: https://izlik.org/JA44ZU55ZY

ISNAD

Ismail, Ismail - Sunaryo, Elly Irma - Kordja, Baharuddin - Nurkhotimah, Ade - Mahmuddin, Suparta. “Effect in Vitro of Areca Catechu Ethanol Extract Partition As Anthelmintics Against Roundworm”. Journal of Research in Pharmacy 28/2 (June 1, 2025): 571-578. https://izlik.org/JA44ZU55ZY.

JAMA

1.Ismail I, Sunaryo EI, Kordja B, Nurkhotimah A, Mahmuddin S. Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm. J. Res. Pharm. 2025;28:571–578.

MLA

Ismail, Ismail, et al. “Effect in Vitro of Areca Catechu Ethanol Extract Partition As Anthelmintics Against Roundworm”. Journal of Research in Pharmacy, vol. 28, no. 2, June 2025, pp. 571-8, https://izlik.org/JA44ZU55ZY.

Vancouver

1.Ismail Ismail, Elly Irma Sunaryo, Baharuddin Kordja, Ade Nurkhotimah, Suparta Mahmuddin. Effect in vitro of Areca catechu ethanol extract partition as anthelmintics against roundworm. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(2):571-8. Available from: https://izlik.org/JA44ZU55ZY