Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies

Evren Atlıhan Gündoğdu; Meliha Ekinci; Emre Özgenç; Emine Selin Demir; Derya İlem-özdemir

Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies

Abstract

In this study, we aimed to develop new lipid based nanoparticles (LPNs) and radiolabeled LPNs with [99mTc]Tc-HMPAO to investigate its cell binding capacity comparatively with [99mTc]Tc-HMPAO on different cancer cells. According to obtained results, LPNs with zeta potential of -27.4 ± 0.95 mV, particle size of 93.5 ± 1.17 nm, and polydispersity index of 0.35 ± 0.04 were successfully developed. The optimum radiolabeling efficiency was found to be above 90% at 15-min of incubation time. The cell binding capacity of [99mTc]Tc-HMPAO-LPNs was found to be higher than [99mTc]Tc-HMPAO in cancer cell lines. The results demonstrated that [99mTc]Tc-HMPAO-LPNs may be a promising agent for cancer diagnosis alternatively to [99mTc]Tc-HMPAO.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Evren Atlıhan Gündoğdu
Türkiye

Meliha Ekinci ^*
Türkiye

Emre Özgenç
Türkiye

Emine Selin Demir This is me
Türkiye

Derya İlem-özdemir
Türkiye

Publication Date

June 28, 2025

Submission Date

May 21, 2021

Acceptance Date

November 15, 2021

Published in Issue

Year 2022 Volume: 26 Number: 1

IZ

https://izlik.org/JA72JR94FB

Cite

RIS / Bibtex

APA

Atlıhan Gündoğdu, E., Ekinci, M., Özgenç, E., Demir, E. S., & İlem-özdemir, D. (2025). Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies. Journal of Research in Pharmacy, 26(1), 88-101. https://izlik.org/JA72JR94FB

AMA

1.Atlıhan Gündoğdu E, Ekinci M, Özgenç E, Demir ES, İlem-özdemir D. Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies. J. Res. Pharm. 2025;26(1):88-101. https://izlik.org/JA72JR94FB

Chicago

Atlıhan Gündoğdu, Evren, Meliha Ekinci, Emre Özgenç, Emine Selin Demir, and Derya İlem-özdemir. 2025. “Development and Radiolabeling of Lipid Nanoparticles With [99mTc]Tc-HMPAO: Characterization, Stability, Cytotoxicity and Cell Binding Studies”. Journal of Research in Pharmacy 26 (1): 88-101. https://izlik.org/JA72JR94FB.

EndNote

Atlıhan Gündoğdu E, Ekinci M, Özgenç E, Demir ES, İlem-özdemir D (June 1, 2025) Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies. Journal of Research in Pharmacy 26 1 88–101.

IEEE

[1]E. Atlıhan Gündoğdu, M. Ekinci, E. Özgenç, E. S. Demir, and D. İlem-özdemir, “Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies”, J. Res. Pharm., vol. 26, no. 1, pp. 88–101, June 2025, [Online]. Available: https://izlik.org/JA72JR94FB

ISNAD

Atlıhan Gündoğdu, Evren - Ekinci, Meliha - Özgenç, Emre - Demir, Emine Selin - İlem-özdemir, Derya. “Development and Radiolabeling of Lipid Nanoparticles With [99mTc]Tc-HMPAO: Characterization, Stability, Cytotoxicity and Cell Binding Studies”. Journal of Research in Pharmacy 26/1 (June 1, 2025): 88-101. https://izlik.org/JA72JR94FB.

JAMA

1.Atlıhan Gündoğdu E, Ekinci M, Özgenç E, Demir ES, İlem-özdemir D. Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies. J. Res. Pharm. 2025;26:88–101.

MLA

Atlıhan Gündoğdu, Evren, et al. “Development and Radiolabeling of Lipid Nanoparticles With [99mTc]Tc-HMPAO: Characterization, Stability, Cytotoxicity and Cell Binding Studies”. Journal of Research in Pharmacy, vol. 26, no. 1, June 2025, pp. 88-101, https://izlik.org/JA72JR94FB.

Vancouver

1.Evren Atlıhan Gündoğdu, Meliha Ekinci, Emre Özgenç, Emine Selin Demir, Derya İlem-özdemir. Development and radiolabeling of lipid nanoparticles with [99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(1):88-101. Available from: https://izlik.org/JA72JR94FB