The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization

Juste Baranauskaıte Ortasöz; Burcu Üner; Gülengül Duman; Çetin Taş

The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization

Abstract

The potential antimicrobial and antioxidant benefit of high levels of ursolic, rosmarinic acids and carvacrol in oregano extract has been limited until now by poor bioavailability arising from the low aqueous-phase solubility and slow dissolution behavior of the freeze-dried extract. To address this issue, microencapsulation technique had been used to solve above mentioned problems and to protect active substances from deteriorating due to environmental conditions, such as moisture, oxidation. The experimental settings were performed by statistical mixture experimental design. Moreover, microcapsules and freeze-dried extract were compared to ascertain the merit of microcapsules as a carriers for these poorly aqueous-soluble compounds. When the wall material solution contained 1.43 g of maltodextrin, 4.17 g of gum arabic, 14.39 g of modified starch, and 20 g of ethanol oregano extract, the yield of oregano’s active compounds, ursolic, rosmarinic acids and carvacrol, were 0.98 mg/g, 3.38 mg/g and 3.38 mg/g respectively. In particular, the release profile of ursolic, rosmarinic acids and carvacrol had levelled off after 15 minutes, depicting an impressive 2.7- 3.0 fold increase compared to the freeze-dried control extract. The results imply that all actives can be conveniently delivered via oral and mucosal routes by first internalizing oregano extracts into appropriately engineered microcapsules.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Sciences

Journal Section

Research Article

Authors

Juste Baranauskaıte Ortasöz ^*
Türkiye

Burcu Üner This is me
Türkiye

Gülengül Duman
Türkiye

Çetin Taş
Türkiye

Publication Date

June 28, 2025

Submission Date

June 28, 2021

Acceptance Date

December 12, 2021

Published in Issue

Year 2022 Volume: 26 Number: 1

IZ

https://izlik.org/JA27DZ74EH

Cite

RIS / Bibtex

APA

Baranauskaıte Ortasöz, J., Üner, B., Duman, G., & Taş, Ç. (2025). The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. Journal of Research in Pharmacy, 26(1), 102-111. https://izlik.org/JA27DZ74EH

AMA

1.Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. 2025;26(1):102-111. https://izlik.org/JA27DZ74EH

Chicago

Baranauskaıte Ortasöz, Juste, Burcu Üner, Gülengül Duman, and Çetin Taş. 2025. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy 26 (1): 102-11. https://izlik.org/JA27DZ74EH.

EndNote

Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç (June 1, 2025) The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. Journal of Research in Pharmacy 26 1 102–111.

IEEE

[1]J. Baranauskaıte Ortasöz, B. Üner, G. Duman, and Ç. Taş, “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”, J. Res. Pharm., vol. 26, no. 1, pp. 102–111, June 2025, [Online]. Available: https://izlik.org/JA27DZ74EH

ISNAD

Baranauskaıte Ortasöz, Juste - Üner, Burcu - Duman, Gülengül - Taş, Çetin. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy 26/1 (June 1, 2025): 102-111. https://izlik.org/JA27DZ74EH.

JAMA

1.Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. 2025;26:102–111.

MLA

Baranauskaıte Ortasöz, Juste, et al. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy, vol. 26, no. 1, June 2025, pp. 102-11, https://izlik.org/JA27DZ74EH.

Vancouver

1.Juste Baranauskaıte Ortasöz, Burcu Üner, Gülengül Duman, Çetin Taş. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(1):102-11. Available from: https://izlik.org/JA27DZ74EH