Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls

Bayram Yüksel; Nilgün Şen; Vugar Ali Türksoy; Engin Tutkun; Tülin Söylemezoğlu

Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls

Abstract

The main goal of this study was to investigate the effect of exposure time and smoking habit on arsenic levels in biological samples of workers occupationally exposed to metals in comparison with non-occupational residents in Turkey. Blood, urine and hair samples were collected from 95 metal workers at Ankara Occupational Diseases Hospital, Turkey. Similarly, 94 hair samples were taken from controls. Arsenic levels in biological samples were measured using Graphite Furnace Atomic Absorption Spectrometry (GFAAS) equipped with Zeeman background correction and Hydride Generation Atomic Absorption Spectrometry (HGAAS). In metal workers; mean hair-arsenic levels of the smokers group (2.05 ±1.97 mg As/kg) was found to be significantly higher than the mean of the hair-arsenic levels of non-smokers group 1.80±1.79 mg As/kg (p<0.05). Mean hair-arsenic levels of exposure time group (4-10 years) was found (2.34±2.21 mg As/kg) to be significantly higher than the arithmetic mean of exposure time group (1-3 years) (1.39 ±1.25 mg As/kg, p<0.01). As for the control group, mean of hair-arsenic levels in the smokers group (0.133 ±0.012 mg As/kg) was found to be significantly higher than the mean of the hair-arsenic levels of non-smokers group (0.101±0.006 mg As/kg, p<0.05). In addition, mean hair arsenic level in metal workers (1.81 ±1.79 mg As/kg) was found significantly higher than mean hair arsenic level in control group (0.115 ±0.006 mg As/kg, p=0.00). Smoking increased the hair arsenic levels significantly both in metal workers and controls. The hair arsenic levels significantly enhanced with ascending exposure time. In addition, metal workers had significantly higher hair arsenic levels than controls. However, there was no significant effect detected in terms of urine and blood arsenic levels.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Bayram Yüksel ^*
0000-0001-7686-8648
Türkiye

Nilgün Şen
0000-0002-1997-1312
Türkiye

Vugar Ali Türksoy
0000-0002-3545-3945
Türkiye

Engin Tutkun
0000-0003-2215-0424
Türkiye

Tülin Söylemezoğlu
0000-0002-6779-164X
Türkiye

Publication Date

June 27, 2025

Submission Date

August 7, 2017

Acceptance Date

October 19, 2017

Published in Issue

Year 2018 Volume: 22 Number: 2

IZ

https://izlik.org/JA54ZR99RS

Cite

RIS / Bibtex

APA

Yüksel, B., Şen, N., Türksoy, V. A., Tutkun, E., & Söylemezoğlu, T. (2025). Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls. Journal of Research in Pharmacy, 22(2), 218-226. https://izlik.org/JA54ZR99RS

AMA

1.Yüksel B, Şen N, Türksoy VA, Tutkun E, Söylemezoğlu T. Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls. J. Res. Pharm. 2025;22(2):218-226. https://izlik.org/JA54ZR99RS

Chicago

Yüksel, Bayram, Nilgün Şen, Vugar Ali Türksoy, Engin Tutkun, and Tülin Söylemezoğlu. 2025. “Effect of Exposure Time and Smoking Habit on Arsenic Levels in Biological Samples of Metal Workers in Comparison With Controls”. Journal of Research in Pharmacy 22 (2): 218-26. https://izlik.org/JA54ZR99RS.

EndNote

Yüksel B, Şen N, Türksoy VA, Tutkun E, Söylemezoğlu T (June 1, 2025) Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls. Journal of Research in Pharmacy 22 2 218–226.

IEEE

[1]B. Yüksel, N. Şen, V. A. Türksoy, E. Tutkun, and T. Söylemezoğlu, “Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls”, J. Res. Pharm., vol. 22, no. 2, pp. 218–226, June 2025, [Online]. Available: https://izlik.org/JA54ZR99RS

ISNAD

Yüksel, Bayram - Şen, Nilgün - Türksoy, Vugar Ali - Tutkun, Engin - Söylemezoğlu, Tülin. “Effect of Exposure Time and Smoking Habit on Arsenic Levels in Biological Samples of Metal Workers in Comparison With Controls”. Journal of Research in Pharmacy 22/2 (June 1, 2025): 218-226. https://izlik.org/JA54ZR99RS.

JAMA

1.Yüksel B, Şen N, Türksoy VA, Tutkun E, Söylemezoğlu T. Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls. J. Res. Pharm. 2025;22:218–226.

MLA

Yüksel, Bayram, et al. “Effect of Exposure Time and Smoking Habit on Arsenic Levels in Biological Samples of Metal Workers in Comparison With Controls”. Journal of Research in Pharmacy, vol. 22, no. 2, June 2025, pp. 218-26, https://izlik.org/JA54ZR99RS.

Vancouver

1.Bayram Yüksel, Nilgün Şen, Vugar Ali Türksoy, Engin Tutkun, Tülin Söylemezoğlu. Effect of exposure time and smoking habit on arsenic levels in biological samples of metal workers in comparison with controls. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(2):218-26. Available from: https://izlik.org/JA54ZR99RS