Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety

Year 2018, Volume: 22 Issue: 2, 237 - 248, 27.06.2025

Nuray Ulusoy Güzeldemirci , Erkan Pehlivan , Lieve Naesens

https://izlik.org/JA57NZ47KY

Abstract

A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- and RNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3- Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayed modest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1 Virginia/ATCC3/2009 (cytotoxicity >100 µM). Compounds 6 and 11 displayed activity against vesicular stomatitis virus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 µM) and 2 µM (cytotoxicity 20 µM), respectively). Neither of the compounds was active against HIV.

Keywords

antiviral activity , imidazo[2,1-b]thiazoles , 4-thiazolidines , synthesis

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