Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety

Nuray Ulusoy Güzeldemirci; Erkan Pehlivan; Lieve Naesens

Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety

Abstract

A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- and RNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3- Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayed modest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1 Virginia/ATCC3/2009 (cytotoxicity >100 µM). Compounds 6 and 11 displayed activity against vesicular stomatitis virus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 µM) and 2 µM (cytotoxicity 20 µM), respectively). Neither of the compounds was active against HIV.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry

Journal Section

Research Article

Authors

Nuray Ulusoy Güzeldemirci ^*
0000-0002-4495-4282
Türkiye

Erkan Pehlivan
0000-0001-9891-3542
Türkiye

Lieve Naesens This is me
0000-0001-9742-9302
Belgium

Publication Date

June 27, 2025

Submission Date

August 27, 2017

Acceptance Date

December 2, 2017

Published in Issue

Year 2018 Volume: 22 Number: 2

IZ

https://izlik.org/JA57NZ47KY

Cite

RIS / Bibtex

APA

Ulusoy Güzeldemirci, N., Pehlivan, E., & Naesens, L. (2025). Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Journal of Research in Pharmacy, 22(2), 237-248. https://izlik.org/JA57NZ47KY

AMA

1.Ulusoy Güzeldemirci N, Pehlivan E, Naesens L. Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. J. Res. Pharm. 2025;22(2):237-248. https://izlik.org/JA57NZ47KY

Chicago

Ulusoy Güzeldemirci, Nuray, Erkan Pehlivan, and Lieve Naesens. 2025. “Synthesis and Antiviral Activity Evaluation of New 4-Thiazolidinones Bearing an Imidazo[2,1-B]thiazole Moiety”. Journal of Research in Pharmacy 22 (2): 237-48. https://izlik.org/JA57NZ47KY.

EndNote

Ulusoy Güzeldemirci N, Pehlivan E, Naesens L (June 1, 2025) Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. Journal of Research in Pharmacy 22 2 237–248.

IEEE

[1]N. Ulusoy Güzeldemirci, E. Pehlivan, and L. Naesens, “Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety”, J. Res. Pharm., vol. 22, no. 2, pp. 237–248, June 2025, [Online]. Available: https://izlik.org/JA57NZ47KY

ISNAD

Ulusoy Güzeldemirci, Nuray - Pehlivan, Erkan - Naesens, Lieve. “Synthesis and Antiviral Activity Evaluation of New 4-Thiazolidinones Bearing an Imidazo[2,1-B]thiazole Moiety”. Journal of Research in Pharmacy 22/2 (June 1, 2025): 237-248. https://izlik.org/JA57NZ47KY.

JAMA

1.Ulusoy Güzeldemirci N, Pehlivan E, Naesens L. Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. J. Res. Pharm. 2025;22:237–248.

MLA

Ulusoy Güzeldemirci, Nuray, et al. “Synthesis and Antiviral Activity Evaluation of New 4-Thiazolidinones Bearing an Imidazo[2,1-B]thiazole Moiety”. Journal of Research in Pharmacy, vol. 22, no. 2, June 2025, pp. 237-48, https://izlik.org/JA57NZ47KY.

Vancouver

1.Nuray Ulusoy Güzeldemirci, Erkan Pehlivan, Lieve Naesens. Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(2):237-48. Available from: https://izlik.org/JA57NZ47KY