Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers

Serap Ayaz Seyhan; Ayşe Betül Demirel; Sümeyye Cesur; Dilek Bilgiç Alkaya

Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers

Abstract

The use of natural compounds such as biocompatible and non-toxic plant extracts, without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials produced by electrospinning of bioactive plant extracts. Electrospun nanofibers have very large surface area, controllable pore size, and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly ethylene glycol (PEG) and poly-lactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. The ethanol-water extract of the root parts of the Rheum ribes L. plant has antioxidant, antimicrobial, and antiurease effects. In this study, the characterization and performance of electrospun Rheum ribes L.-loaded (20 mg, 40 mg, and 60 mg in 20mL) poly (lactic acid) (PLA) (8%, w/v) /Polyethylene glycol (PEG) (1%, w/v) /Tween 80 (3%, w/v) nanofibrous mats for skin tissue engineering were investigated. Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis were carried out after the production process. According to the results obtained, Rheum ribes L.- loaded PLA/PEG nanofibers have smooth fiber morphology in fine structure without beads, proper tensile strength and antioxidant activity. Consequently, Rheum ribes L.-loaded nanofibrous mats are suitable for skin tissue engineering applications.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Serap Ayaz Seyhan ^*
0000-0001-5908-2766
Türkiye

Ayşe Betül Demirel This is me
0000-0003-1050-3966
Türkiye

Sümeyye Cesur
0000-0001-5050-1303
Türkiye

Dilek Bilgiç Alkaya
0000-0002-7837-0250
Türkiye

Publication Date

June 28, 2025

Submission Date

December 12, 2022

Acceptance Date

December 21, 2022

Published in Issue

Year 2023 Volume: 27 Number: 1

IZ

https://izlik.org/JA58EP36BF

Cite

RIS / Bibtex

APA

Ayaz Seyhan, S., Demirel, A. B., Cesur, S., & Bilgiç Alkaya, D. (2025). Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers. Journal of Research in Pharmacy, 27(1), 146-156. https://izlik.org/JA58EP36BF

AMA

1.Ayaz Seyhan S, Demirel AB, Cesur S, Bilgiç Alkaya D. Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers. J. Res. Pharm. 2025;27(1):146-156. https://izlik.org/JA58EP36BF

Chicago

Ayaz Seyhan, Serap, Ayşe Betül Demirel, Sümeyye Cesur, and Dilek Bilgiç Alkaya. 2025. “Production, Characterization, and Antioxidant Activity Evaluation of Rheum Ribes L. Extract-Loaded PLA PEG Nanofibers”. Journal of Research in Pharmacy 27 (1): 146-56. https://izlik.org/JA58EP36BF.

EndNote

Ayaz Seyhan S, Demirel AB, Cesur S, Bilgiç Alkaya D (June 1, 2025) Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers. Journal of Research in Pharmacy 27 1 146–156.

IEEE

[1]S. Ayaz Seyhan, A. B. Demirel, S. Cesur, and D. Bilgiç Alkaya, “Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers”, J. Res. Pharm., vol. 27, no. 1, pp. 146–156, June 2025, [Online]. Available: https://izlik.org/JA58EP36BF

ISNAD

Ayaz Seyhan, Serap - Demirel, Ayşe Betül - Cesur, Sümeyye - Bilgiç Alkaya, Dilek. “Production, Characterization, and Antioxidant Activity Evaluation of Rheum Ribes L. Extract-Loaded PLA PEG Nanofibers”. Journal of Research in Pharmacy 27/1 (June 1, 2025): 146-156. https://izlik.org/JA58EP36BF.

JAMA

1.Ayaz Seyhan S, Demirel AB, Cesur S, Bilgiç Alkaya D. Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers. J. Res. Pharm. 2025;27:146–156.

MLA

Ayaz Seyhan, Serap, et al. “Production, Characterization, and Antioxidant Activity Evaluation of Rheum Ribes L. Extract-Loaded PLA PEG Nanofibers”. Journal of Research in Pharmacy, vol. 27, no. 1, June 2025, pp. 146-5, https://izlik.org/JA58EP36BF.

Vancouver

1.Serap Ayaz Seyhan, Ayşe Betül Demirel, Sümeyye Cesur, Dilek Bilgiç Alkaya. Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(1):146-5. Available from: https://izlik.org/JA58EP36BF