Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers

Rita Bhatta; Mohammad Salim Hossain; Sujan Banik; Md. Mizanur Rahman Moghal; Mamun Or Rashid; Mariyam Akter

Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers

Abstract

Using ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricate low-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivatives are more viscous where biopolymers form gels more easily. Xanthan gum can’t shape a solid gel, result in fragmentation of gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tablet by direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients as per formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tablet in a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability, surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swelling index, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulated products exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences were found in drug release among different formulations (p ˂0.05) in all cases. Among all of formulations, F11, F12 and F13 containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitro residence time.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Rita Bhatta This is me
0000-0001-9731-6367
Bangladesh

Mohammad Salim Hossain ^* This is me
0000-0002-5710-1115
Bangladesh

Sujan Banik
0000-0001-9639-6836
Bangladesh

Md. Mizanur Rahman Moghal
0000-0002-0553-1447
Bangladesh

Mamun Or Rashid This is me
0000-0002-3555-6354
Bangladesh

Mariyam Akter This is me
Bangladesh

Publication Date

June 27, 2025

Submission Date

October 25, 2017

Acceptance Date

December 8, 2017

Published in Issue

Year 2018 Volume: 22 Number: 2

IZ

https://izlik.org/JA98CD68MS

Cite

RIS / Bibtex

APA

Bhatta, R., Hossain, M. S., Banik, S., Moghal, M. M. R., Rashid, M. O., & Akter, M. (2025). Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. Journal of Research in Pharmacy, 22(2), 286-298. https://izlik.org/JA98CD68MS

AMA

1.Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. 2025;22(2):286-298. https://izlik.org/JA98CD68MS

Chicago

Bhatta, Rita, Mohammad Salim Hossain, Sujan Banik, Md. Mizanur Rahman Moghal, Mamun Or Rashid, and Mariyam Akter. 2025. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy 22 (2): 286-98. https://izlik.org/JA98CD68MS.

EndNote

Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M (June 1, 2025) Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. Journal of Research in Pharmacy 22 2 286–298.

IEEE

[1]R. Bhatta, M. S. Hossain, S. Banik, M. M. R. Moghal, M. O. Rashid, and M. Akter, “Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers”, J. Res. Pharm., vol. 22, no. 2, pp. 286–298, June 2025, [Online]. Available: https://izlik.org/JA98CD68MS

ISNAD

Bhatta, Rita - Hossain, Mohammad Salim - Banik, Sujan - Moghal, Md. Mizanur Rahman - Rashid, Mamun Or - Akter, Mariyam. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy 22/2 (June 1, 2025): 286-298. https://izlik.org/JA98CD68MS.

JAMA

1.Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. 2025;22:286–298.

MLA

Bhatta, Rita, et al. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy, vol. 22, no. 2, June 2025, pp. 286-98, https://izlik.org/JA98CD68MS.

Vancouver

1.Rita Bhatta, Mohammad Salim Hossain, Sujan Banik, Md. Mizanur Rahman Moghal, Mamun Or Rashid, Mariyam Akter. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(2):286-98. Available from: https://izlik.org/JA98CD68MS