Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Shima Azizi; Arash Ghasemi; Hossein Asgarian-omran; Zohreh Zal; Azadeh Montazeri; Hooman Yazdannejat; Sj Hosseinimehr

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Abstract

Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

Keywords

References

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Details

Primary Language

English

Subjects

Radiopharmacy

Journal Section

Research Article

Authors

Shima Azizi This is me
Iran

Arash Ghasemi This is me
0000-0002-9040-6746
Iran

Hossein Asgarian-omran This is me
0000-0003-3816-8792
Iran

Zohreh Zal This is me
Iran

Azadeh Montazeri This is me
Iran

Hooman Yazdannejat This is me
Iran

Sj Hosseinimehr ^*
Iran

Publication Date

June 27, 2025

Submission Date

October 22, 2017

Acceptance Date

November 8, 2017

Published in Issue

Year 2018 Volume: 22 Number: 2

IZ

https://izlik.org/JA44CX57XB

Cite

RIS / Bibtex

APA

Azizi, S., Ghasemi, A., Asgarian-omran, H., Zal, Z., Montazeri, A., Yazdannejat, H., & Hosseinimehr, S. (2025). Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. Journal of Research in Pharmacy, 22(2), 307-313. https://izlik.org/JA44CX57XB

AMA

1.Azizi S, Ghasemi A, Asgarian-omran H, et al. Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. J. Res. Pharm. 2025;22(2):307-313. https://izlik.org/JA44CX57XB

Chicago

Azizi, Shima, Arash Ghasemi, Hossein Asgarian-omran, et al. 2025. “Cerium Oxide Nanoparticles Sensitize Non-Small Lung Cancer Cell to Ionizing Radiation”. Journal of Research in Pharmacy 22 (2): 307-13. https://izlik.org/JA44CX57XB.

EndNote

Azizi S, Ghasemi A, Asgarian-omran H, Zal Z, Montazeri A, Yazdannejat H, Hosseinimehr S (June 1, 2025) Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. Journal of Research in Pharmacy 22 2 307–313.

IEEE

[1]S. Azizi et al., “Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation”, J. Res. Pharm., vol. 22, no. 2, pp. 307–313, June 2025, [Online]. Available: https://izlik.org/JA44CX57XB

ISNAD

Azizi, Shima - Ghasemi, Arash - Asgarian-omran, Hossein - Zal, Zohreh - Montazeri, Azadeh - Yazdannejat, Hooman - Hosseinimehr, Sj. “Cerium Oxide Nanoparticles Sensitize Non-Small Lung Cancer Cell to Ionizing Radiation”. Journal of Research in Pharmacy 22/2 (June 1, 2025): 307-313. https://izlik.org/JA44CX57XB.

JAMA

1.Azizi S, Ghasemi A, Asgarian-omran H, Zal Z, Montazeri A, Yazdannejat H, Hosseinimehr S. Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. J. Res. Pharm. 2025;22:307–313.

MLA

Azizi, Shima, et al. “Cerium Oxide Nanoparticles Sensitize Non-Small Lung Cancer Cell to Ionizing Radiation”. Journal of Research in Pharmacy, vol. 22, no. 2, June 2025, pp. 307-13, https://izlik.org/JA44CX57XB.

Vancouver

1.Shima Azizi, Arash Ghasemi, Hossein Asgarian-omran, Zohreh Zal, Azadeh Montazeri, Hooman Yazdannejat, Sj Hosseinimehr. Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation. J. Res. Pharm. [Internet]. 2025 Jun. 1;22(2):307-13. Available from: https://izlik.org/JA44CX57XB