Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey

İshak Erik; Gözde Kilic; Büşra Korkmaz; Seda Fandakli; Şengül Alpay Karaoğlu; Nurettin Yaylı

Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey

Abstract

In this study, volatile compounds (VCs) in the essential oil (EO), SPME and SPME of n-hexane extract of Vinca major subsp. hirsuta (Boiss.) Stearn were analyzed by GC-FID/MS instrument. A total of 32, 38, and 26 compounds with in the 98.5%, 98.6%, and 98.6% were identified, respectively. As a result of VCs study, (Z)-3-hexenol (36.8%) in the EO, 1,3,5-trimethylbenzene (31,5%) in the SPME, and phenylethyl alcohol (32.8 %) in the SPME of n-hexane extract of V. major subsp. hirsuta were found to be major compounds. Sesquiterpenes (20.6%, and 11.5%) for the HD and SPME, monoterpenes (18.6%) for the SPME of n-hexane extract of V. major subsp. hirsuta were found as the main groups among the terpenic compounds, respectively. Then, the antimicrobial activity of the EO and the solvent extracts (n-hexane, acetonitrile, methanol, and water) of V. major subs. hirsuta against 3 gram negative, 3 gram positive, 1 tuberculosis and 2 fungus were screened. The EO showed the only activity against the Mycobacterium smegmatis ATCC607 (MIC, 152 µg/mL) and Candida albicans ATCC60193 (MIC, 38 µg/mL). The n-hexane extract did not show any activity against all tested microorganisms. The best antimicrobial activity for the acetonitrile, methanol, and water extracts were observed against M. smegmatis with 69 µg/mL, 609 µg/mL, and 437 µg/mL MIC values, respectively. None of the extracts were found to be active to Enterococcus faecalis ATCC29212, Staphylococcus aureus ATCC25923, and Saccharomyces cerevisiae RSKK 251.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

İshak Erik ^*
Türkiye

Gözde Kilic This is me
Türkiye

Büşra Korkmaz
Türkiye

Seda Fandakli
Türkiye

Şengül Alpay Karaoğlu
Türkiye

Nurettin Yaylı
Türkiye

Publication Date

June 28, 2025

Submission Date

February 12, 2021

Acceptance Date

July 5, 2021

Published in Issue

Year 2021 Volume: 25 Number: 5

IZ

https://izlik.org/JA82FS99WJ

Cite

RIS / Bibtex

APA

Erik, İ., Kilic, G., Korkmaz, B., Fandakli, S., Alpay Karaoğlu, Ş., & Yaylı, N. (2025). Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey. Journal of Research in Pharmacy, 25(5), 581-588. https://izlik.org/JA82FS99WJ

AMA

1.Erik İ, Kilic G, Korkmaz B, Fandakli S, Alpay Karaoğlu Ş, Yaylı N. Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey. J. Res. Pharm. 2025;25(5):581-588. https://izlik.org/JA82FS99WJ

Chicago

Erik, İshak, Gözde Kilic, Büşra Korkmaz, Seda Fandakli, Şengül Alpay Karaoğlu, and Nurettin Yaylı. 2025. “Volatile Constituents and Antimicrobial Activity of Vinca Major L. Subsp. Hirsuta (Boiss) Stearn Grown in Turkey”. Journal of Research in Pharmacy 25 (5): 581-88. https://izlik.org/JA82FS99WJ.

EndNote

Erik İ, Kilic G, Korkmaz B, Fandakli S, Alpay Karaoğlu Ş, Yaylı N (July 1, 2025) Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey. Journal of Research in Pharmacy 25 5 581–588.

IEEE

[1]İ. Erik, G. Kilic, B. Korkmaz, S. Fandakli, Ş. Alpay Karaoğlu, and N. Yaylı, “Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey”, J. Res. Pharm., vol. 25, no. 5, pp. 581–588, July 2025, [Online]. Available: https://izlik.org/JA82FS99WJ

ISNAD

Erik, İshak - Kilic, Gözde - Korkmaz, Büşra - Fandakli, Seda - Alpay Karaoğlu, Şengül - Yaylı, Nurettin. “Volatile Constituents and Antimicrobial Activity of Vinca Major L. Subsp. Hirsuta (Boiss) Stearn Grown in Turkey”. Journal of Research in Pharmacy 25/5 (July 1, 2025): 581-588. https://izlik.org/JA82FS99WJ.

JAMA

1.Erik İ, Kilic G, Korkmaz B, Fandakli S, Alpay Karaoğlu Ş, Yaylı N. Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey. J. Res. Pharm. 2025;25:581–588.

MLA

Erik, İshak, et al. “Volatile Constituents and Antimicrobial Activity of Vinca Major L. Subsp. Hirsuta (Boiss) Stearn Grown in Turkey”. Journal of Research in Pharmacy, vol. 25, no. 5, July 2025, pp. 581-8, https://izlik.org/JA82FS99WJ.

Vancouver

1.İshak Erik, Gözde Kilic, Büşra Korkmaz, Seda Fandakli, Şengül Alpay Karaoğlu, Nurettin Yaylı. Volatile constituents and antimicrobial activity of Vinca major L. subsp. hirsuta (Boiss) stearn grown in Turkey. J. Res. Pharm. [Internet]. 2025 Jul. 1;25(5):581-8. Available from: https://izlik.org/JA82FS99WJ