The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation

Saliha Aydın; Mizgin Ermanoğlu; Şükran Özdatlı Kurtuluş; Beyza Nur Yılmaz; Turgut Taşkın; Muhammet Emin Çam

doi:10.29228/jrp.523

The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation

Abstract

Alzheimer's Disease (AD), which is quite prevalent in our society, not only makes the lives of patients and their families more challenging but also brings significant economic burdens. Sideritis species are widely used in folk medicine due to their various effects such as anti-inflammatory, antimicrobial, diuretic, and antispasmodic properties. Although there are many studies with the hypothesis that ROS is effective in the pathogenesis of neurodegenerative diseases, there are not enough studies on Sideritis germanicopolitana Bornm. subsp. viridis Hausskn. ex Bornm. (SGV) and Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm. (SLL) species. In this study, the antioxidant activities of SGV and SLL plant extracts were compared using DPPH, FRAP, and CUPRAC methods to aid in AD treatment research. It was determined that SGV extract has higher DPPH (0.023±0.005 mg/mL), FRAP (1.074± 0.180 mM FeSO4/mg extract) and CUPRAC (2,988± 0,041 mM trolox equivalent/mg extract) activity potential than SLL extract. Additionally, as a result of cytotoxicity studies performed on SH-SY5Y neuroblastoma cells, ethanol extracts of SGV may be more suitable for use in AD at higher concentrations (250 μg/mL).

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Saliha Aydın This is me
Türkiye

Mizgin Ermanoğlu
0000-0003-3146-1988
Türkiye

Şükran Özdatlı Kurtuluş
0000-0002-5735-7276
Türkiye

Beyza Nur Yılmaz This is me
0000-0002-4418-3182
Türkiye

Turgut Taşkın
0000-0001-8475-6478
Türkiye

Muhammet Emin Çam ^*
0000-0001-5398-6801
Türkiye

Publication Date

June 28, 2025

Submission Date

August 29, 2023

Acceptance Date

September 10, 2023

Published in Issue

Year 2023 Volume: 27 Number: 6

DOI

https://doi.org/10.29228/jrp.523

IZ

https://izlik.org/JA68WA42HW

Cite

RIS / Bibtex

APA

Aydın, S., Ermanoğlu, M., Özdatlı Kurtuluş, Ş., Yılmaz, B. N., Taşkın, T., & Çam, M. E. (2025). The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation. Journal of Research in Pharmacy, 27(6), 2353-2361. https://doi.org/10.29228/jrp.523

AMA

1.Aydın S, Ermanoğlu M, Özdatlı Kurtuluş Ş, Yılmaz BN, Taşkın T, Çam ME. The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation. J. Res. Pharm. 2025;27(6):2353-2361. doi:10.29228/jrp.523

Chicago

Aydın, Saliha, Mizgin Ermanoğlu, Şükran Özdatlı Kurtuluş, Beyza Nur Yılmaz, Turgut Taşkın, and Muhammet Emin Çam. 2025. “The Effect of Sideritis Species on Alzheimer’s Disease: In Vitro Evaluation”. Journal of Research in Pharmacy 27 (6): 2353-61. https://doi.org/10.29228/jrp.523.

EndNote

Aydın S, Ermanoğlu M, Özdatlı Kurtuluş Ş, Yılmaz BN, Taşkın T, Çam ME (July 1, 2025) The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation. Journal of Research in Pharmacy 27 6 2353–2361.

IEEE

[1]S. Aydın, M. Ermanoğlu, Ş. Özdatlı Kurtuluş, B. N. Yılmaz, T. Taşkın, and M. E. Çam, “The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation”, J. Res. Pharm., vol. 27, no. 6, pp. 2353–2361, July 2025, doi: 10.29228/jrp.523.

ISNAD

Aydın, Saliha - Ermanoğlu, Mizgin - Özdatlı Kurtuluş, Şükran - Yılmaz, Beyza Nur - Taşkın, Turgut - Çam, Muhammet Emin. “The Effect of Sideritis Species on Alzheimer’s Disease: In Vitro Evaluation”. Journal of Research in Pharmacy 27/6 (July 1, 2025): 2353-2361. https://doi.org/10.29228/jrp.523.

JAMA

1.Aydın S, Ermanoğlu M, Özdatlı Kurtuluş Ş, Yılmaz BN, Taşkın T, Çam ME. The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation. J. Res. Pharm. 2025;27:2353–2361.

MLA

Aydın, Saliha, et al. “The Effect of Sideritis Species on Alzheimer’s Disease: In Vitro Evaluation”. Journal of Research in Pharmacy, vol. 27, no. 6, July 2025, pp. 2353-61, doi:10.29228/jrp.523.

Vancouver

1.Saliha Aydın, Mizgin Ermanoğlu, Şükran Özdatlı Kurtuluş, Beyza Nur Yılmaz, Turgut Taşkın, Muhammet Emin Çam. The effect of Sideritis species on Alzheimer’s disease: In vitro evaluation. J. Res. Pharm. 2025 Jul. 1;27(6):2353-61. doi:10.29228/jrp.523