Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Ceren Öztürk; Nisa Beril Şen; Etil Güzelmeriç; Hasan Kırmızıbekmez

Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Abstract

Two secoiridoid glycosides, lonicejaposide I (1) and secologanin dimethyl acetal (2), six flavonoids, isoorientin (3) hesperidin (4), apigenin 7-O-neohesperidoside (5), luteolin 7-O-b-D-glucopyranoside (6), kaempferol 3- O-(3'',6''-di-(E)-p-coumaroyl)-b-D-glucopyranoside (7), and kaempferol 3-O-(3''-O-acetyl, 6''-O-(E)-p-coumaroyl)-b-Dglycopyranoside (8), two caffeoylquinic acid derivatives, chlorogenic acid (9) and 3,5-dicaffeoylquinic acid (10) were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase (XO) inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Ceren Öztürk ^* This is me
0009-0008-5642-1601
Türkiye

Nisa Beril Şen This is me
0000-0001-8422-8835
Türkiye

Etil Güzelmeriç
0000-0001-9696-3271
Türkiye

Hasan Kırmızıbekmez
0000-0002-6118-8225
Türkiye

Publication Date

June 28, 2025

Submission Date

March 31, 2023

Acceptance Date

June 19, 2023

Published in Issue

Year 2024 Volume: 28 Number: 1

IZ

https://izlik.org/JA27UH43PL

Cite

RIS / Bibtex

APA

Öztürk, C., Şen, N. B., Güzelmeriç, E., & Kırmızıbekmez, H. (2025). Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. Journal of Research in Pharmacy, 28(1), 79-88. https://izlik.org/JA27UH43PL

AMA

1.Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. 2025;28(1):79-88. https://izlik.org/JA27UH43PL

Chicago

Öztürk, Ceren, Nisa Beril Şen, Etil Güzelmeriç, and Hasan Kırmızıbekmez. 2025. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy 28 (1): 79-88. https://izlik.org/JA27UH43PL.

EndNote

Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H (June 1, 2025) Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. Journal of Research in Pharmacy 28 1 79–88.

IEEE

[1]C. Öztürk, N. B. Şen, E. Güzelmeriç, and H. Kırmızıbekmez, “Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities”, J. Res. Pharm., vol. 28, no. 1, pp. 79–88, June 2025, [Online]. Available: https://izlik.org/JA27UH43PL

ISNAD

Öztürk, Ceren - Şen, Nisa Beril - Güzelmeriç, Etil - Kırmızıbekmez, Hasan. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy 28/1 (June 1, 2025): 79-88. https://izlik.org/JA27UH43PL.

JAMA

1.Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. 2025;28:79–88.

MLA

Öztürk, Ceren, et al. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy, vol. 28, no. 1, June 2025, pp. 79-88, https://izlik.org/JA27UH43PL.

Vancouver

1.Ceren Öztürk, Nisa Beril Şen, Etil Güzelmeriç, Hasan Kırmızıbekmez. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. [Internet]. 2025 Jun. 1;28(1):79-88. Available from: https://izlik.org/JA27UH43PL