D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells

Mustafa Kotmakçı; Ayşe Gülten Kantarci; Vildan Bozok Çetintaş

D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells

Abstract

Most of the cancer cases are detected in advanced stage when surgical intervention is not possible, thus chemotherapy is the only treatment option. In the majority of the cases, chemotherapy has severe side effects and cancer cells rapidly develop resistance to the treatment. Therefore, milder treatment options for chemotherapy patients are needed. The aim of this study was to investigate the potential of a vitamin E derivative, D-α-tocopherol polyethylene glycol (1000) succinate, in a microemulsion formulation to increase the anticancer activity of cisplatin. The vitamin E derivative was formulated as microemulsions with particle sizes between 100 and 150 nm, and zeta potential values between +4.1 and +5.8 mV. The IC50 value of the selected microemulsion was determined in human lung epidermoid carcinoma (Calu1) and adenocarcinoma (A549) cells. The microemulsion components had no significant effect on the cell viability. Co-treatment of cisplatin and the microemulsion increased the level of early mediator caspases, caspase-8 and caspase-9, and the effector caspase-3 in the cancer cells. Simultaneous application of the microemulsion with cisplatin enhanced the anticancer effect of the chemotherapy drug. The novel microemulsion has the potential to reduce the required dose of cisplatin for effective cancer treatments.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Mustafa Kotmakçı ^*
Türkiye

Ayşe Gülten Kantarci This is me
0000-0001-8813-5353
Türkiye

Vildan Bozok Çetintaş
Türkiye

Publication Date

June 28, 2025

Submission Date

May 3, 2023

Acceptance Date

May 22, 2023

Published in Issue

Year 2023 Volume: 27 Number: 6

IZ

https://izlik.org/JA98EY75TD

Cite

RIS / Bibtex

APA

Kotmakçı, M., Kantarci, A. G., & Bozok Çetintaş, V. (2025). D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells. Journal of Research in Pharmacy, 27(6), 2389-2398. https://izlik.org/JA98EY75TD

AMA

1.Kotmakçı M, Kantarci AG, Bozok Çetintaş V. D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells. J. Res. Pharm. 2025;27(6):2389-2398. https://izlik.org/JA98EY75TD

Chicago

Kotmakçı, Mustafa, Ayşe Gülten Kantarci, and Vildan Bozok Çetintaş. 2025. “D-a-Tocopherol Polyethylene Glycol (1000) Succinate - Containing Microemulsion Enhances the Anticancer Effect of Cisplatin in Human Lung Epidermoid Carcinoma Cells”. Journal of Research in Pharmacy 27 (6): 2389-98. https://izlik.org/JA98EY75TD.

EndNote

Kotmakçı M, Kantarci AG, Bozok Çetintaş V (July 1, 2025) D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells. Journal of Research in Pharmacy 27 6 2389–2398.

IEEE

[1]M. Kotmakçı, A. G. Kantarci, and V. Bozok Çetintaş, “D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells”, J. Res. Pharm., vol. 27, no. 6, pp. 2389–2398, July 2025, [Online]. Available: https://izlik.org/JA98EY75TD

ISNAD

Kotmakçı, Mustafa - Kantarci, Ayşe Gülten - Bozok Çetintaş, Vildan. “D-a-Tocopherol Polyethylene Glycol (1000) Succinate - Containing Microemulsion Enhances the Anticancer Effect of Cisplatin in Human Lung Epidermoid Carcinoma Cells”. Journal of Research in Pharmacy 27/6 (July 1, 2025): 2389-2398. https://izlik.org/JA98EY75TD.

JAMA

1.Kotmakçı M, Kantarci AG, Bozok Çetintaş V. D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells. J. Res. Pharm. 2025;27:2389–2398.

MLA

Kotmakçı, Mustafa, et al. “D-a-Tocopherol Polyethylene Glycol (1000) Succinate - Containing Microemulsion Enhances the Anticancer Effect of Cisplatin in Human Lung Epidermoid Carcinoma Cells”. Journal of Research in Pharmacy, vol. 27, no. 6, July 2025, pp. 2389-98, https://izlik.org/JA98EY75TD.

Vancouver

1.Mustafa Kotmakçı, Ayşe Gülten Kantarci, Vildan Bozok Çetintaş. D-a-tocopherol polyethylene glycol (1000) succinate - containing microemulsion enhances the anticancer effect of cisplatin in human lung epidermoid carcinoma cells. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(6):2389-98. Available from: https://izlik.org/JA98EY75TD