The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease

Ece Guler; Muhammet Emin Çam

The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease

Abstract

Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. In the treatment of AD, there is no drug for radical treatment in the worldwide. Current treatment strategies provide relief to the symptoms. Therefore, curcumin (CUR) was preferred as a promising alternative therapeutic approach in this study. By using the double emulsion solvent evaporation technique, PLGA/PEG nanoparticles were produced and CUR was loaded to these nanoparticles (CNP). After that, the chemical structures and morphologies of CNP and PNP were analyzed by using FTIR and SEM. As a result, it was proven that these nanoparticles were produced by using PLGA and PEG polymers and CUR was loaded to these nanoparticles successfully.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Ece Guler This is me
0000-0002-0639-5029
Türkiye

Muhammet Emin Çam ^*
0000-0001-5398-6801
Türkiye

Publication Date

June 28, 2025

Submission Date

August 29, 2023

Acceptance Date

September 18, 2023

Published in Issue

Year 2023 Volume: 27 Number: 6

IZ

https://izlik.org/JA99SG56XP

Cite

RIS / Bibtex

APA

Guler, E., & Çam, M. E. (2025). The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. Journal of Research in Pharmacy, 27(6), 2399-2404. https://izlik.org/JA99SG56XP

AMA

1.Guler E, Çam ME. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. 2025;27(6):2399-2404. https://izlik.org/JA99SG56XP

Chicago

Guler, Ece, and Muhammet Emin Çam. 2025. “The Production of Curcumin-Loaded PLGA PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy 27 (6): 2399-2404. https://izlik.org/JA99SG56XP.

EndNote

Guler E, Çam ME (July 1, 2025) The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. Journal of Research in Pharmacy 27 6 2399–2404.

IEEE

[1]E. Guler and M. E. Çam, “The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease”, J. Res. Pharm., vol. 27, no. 6, pp. 2399–2404, July 2025, [Online]. Available: https://izlik.org/JA99SG56XP

ISNAD

Guler, Ece - Çam, Muhammet Emin. “The Production of Curcumin-Loaded PLGA PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy 27/6 (July 1, 2025): 2399-2404. https://izlik.org/JA99SG56XP.

JAMA

1.Guler E, Çam ME. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. 2025;27:2399–2404.

MLA

Guler, Ece, and Muhammet Emin Çam. “The Production of Curcumin-Loaded PLGA PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy, vol. 27, no. 6, July 2025, pp. 2399-04, https://izlik.org/JA99SG56XP.

Vancouver

1.Ece Guler, Muhammet Emin Çam. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. [Internet]. 2025 Jul. 1;27(6):2399-404. Available from: https://izlik.org/JA99SG56XP