Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives

Year 2023, Volume: 27 Issue: 6, 2416 - 2424, 28.06.2025

Fatih Tok , Hümeyra Cihangir Kader Şan Cansel Çakır , Yusuf Sıcak , Mehmet Öztürk , Bedia Kaymakçıoğlu

Abstract

In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, 13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48-298.27±8.61 µM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.

Keywords

Sulfonylurea , antioxidant , cholinesterase , tyrosinase , α-amylase , α-glucosidase

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